Results: As well as the expected cytoplasmic occupancy of PfSHMTc during all stages, localization into the mitochondrion and apicoplast see more occurred in a stage-specific manner. Although early trophozoites lacked visible organellar PfSHMTc, a significant percentage of parasites showed such fluorescence during the mid-to-late trophozoite and schizont stages. In the case of the mitochondrion, the majority of parasites in these stages at any given time showed no marked PfSHMTc fluorescence, suggesting that its occupancy of this organelle is of limited duration. PfSHMTm showed a distinctly

more pronounced mitochondrial location through most of the erythrocytic cycle and GFP-tagging of its N-terminal region confirmed the predicted presence of a mitochondrial signal sequence. Within the apicoplast,

a majority of mitotic schizonts showed a marked concentration of PfSHMTc, LOXO-101 whose localization in this organelle was less restricted than for the mitochondrion and persisted from the late trophozoite to the post-mitotic stages. PfSHMTm showed a broadly similar distribution across the cycle, but with a distinctive punctate accumulation towards the ends of elongating apicoplasts. In very late post-mitotic schizonts, both PfSHMTc and PfSHMTm were concentrated in the central region of the parasite that becomes the residual body on erythrocyte lysis and merozoite release.

Conclusions: Both PfSHMTc and PfSHMTm show dynamic, stage-dependent localization AZD8055 in vivo among the different compartments of the parasite and sequence analysis suggests they may also reversibly associate with each other, a factor that may be critical to folate cofactor function, given the apparent lack of enzymic activity of PfSHMTm.”
“N-carboxymethyl chitosans (N-CMC) were synthesized from chitosan in water with chloroacetic acid instead of comparatively expensive glyoxylic acid. The optimal reaction conditions were 90 degrees C and 4 h with a ratio of chloroacetic

acid to chitosan 5 : 1(w/w). The degree of substitution of product exceeded 1.32. The N-carboxymethyl chitosans were characterized by XRD, FTIR, (1)H-NMR, and the water solubility and isoelectric point of N-CMC with different degrees of substitution were determined. FTIR and (1)H-NMR data has confirmed that the substitution reaction occurred on the amino groups. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 119: 3282-3285, 2011″
“A sweetpotato (Ipomoea batatas cv. ‘Jinhongmi’) MADS-box protein cDNA (SRD1) has been isolated from an early stage storage root cDNA library. The role of the SRD1 gene in the formation of the storage root in sweetpotato was investigated by an expression pattern analysis and characterization of SRD1-overexpressing (ox) transgenic sweetpotato plants.

The frequency of complex aberrations correlated with LET.

Conclusion: In lymphocytes www.selleckchem.com/products/OSI-906.html of donors studied in this work chromosome 2 appears to be consistently less sensitive to protons and heavy ions than chromosomes 8 and 14. Complex aberrations appear to be a potential marker of radiation quality.”
“Objective: To evaluate the value of intraoperative laparoscopic ultrasonography (ILUS) in retrolaparoscopic nephron-sparing surgery. Methods: A total of 81 cases were studied during a 5-year period: 38 patients with a benign renal tumor who underwent enucleation of the tumor and 43 patients with a suspected malignant renal tumor who underwent wedge resection

of the tumor. ILUS was used to evaluate renal perfusion, locate the tumor, precisely delineate the tumor border, AR-13324 characterize the tumor, and look for any suspected satellite renal

masses. Results: All procedures were successful without conversion to open surgery. The mean operating time was 106 min for enucleation (range 70150 min) and 114 min for wedge resection (range 80235 min). The mean size of benign tumors was 4.02 cm and that of malignant tumors was 3.13 cm, and all margins were negative. An additional renal artery branch was detected in 11 patients. In 2 cases the operative procedure was changed based on the ILUS findings. No satellite lesion was found in any of the patients with malignant tumors. Conclusions: ILUS provides significant benefit

in retrolaparoscopic nephron-sparing surgery. In a number of situations, especially endogenic lesions, it is an essential surgical tool. Copyright (C) 2012 S. Karger AG, Basel”
“This paper introduces a nonlinear resonant magneto-elastic device with 2 degrees of freedom that can serve as a mechanical frequency multiplier effective for energy harvesting. The device allows energy harvesting at low and extra-low exciting frequencies. The concept of effective frequency multiplication is proposed. The frequency multiplication factor may vary in the range from 2 up to several dozens. The theoretical model, the results of the experiment, and a computer simulation are presented. With a frequency of 3.5 Hz and an amplitude of 12.5 mm of shaker oscillations, the click here experimental setup produces output oscillations that have the principal harmonic of the amplitude 3.55 mm at 14 Hz. The amplitude of the output acceleration is 27 m/s(2), which is 4.5 times the initial acceleration provided by the shaker. The numerical simulation of the setup with different elastic coefficients yields a frequency multiplication factor of 14, and the amplitude of output acceleration is equal to 35 to 60 m/s(2). The operating principle used in the device is supposed to be useful as a principle of inexpensively transforming the mechanical energy with frequency-upconversion. (C) 2011 American Institute of Physics. [doi:10.1063/1.

The cerebellum of H. glaber resembles that of other rodents with the remarkable exception that cerebellar regions that are prominent in the handling of visual information (the central zone, nodular zone, and dorsal paraflocculus) are greatly reduced or absent. In addition, there is a notable increase in size in the posterior zone, consistent with an expanded role for the trigeminal somatosensory system. These data suggest that cerebellar architecture may be substantially modified to serve a particular ecological niche.”
“Objectives: The aim of this article is to review the current state of immediate implants, with their pros and contras, and the clinical indications

and contraindications.

Material and Methods: An exhaustive literature search has been carried out in the COCHRANE

library and MEDLINE electronic databases from 2004 to November 2009. Randomized clinical trials click here and clinical trials focused on single implants placed in fresh extraction sockets were included and compared. A meta-analysis could not be performed due to heterogeneity of the data.

Results: Twenty studies out of 135 articles from the initial search were finally included, which summed up a total of 1139 immediate implants with at least a 12-month follow-up. Our results XMU-MP-1 molecular weight have been compared with other current available papers in the literature reviewed that obtained similar outcomes.

Discussion: Immediate implants have predictable results with several advantages over delayed implant placement. However, technical complications have been described regarding this technique. Also, biomaterials may be needed when the jumping distance is greater than 1mm or any bone defect is present.

Conclusions: Few studies report on success rates rather than survival rates in the literature reviewed. Short-term clinical results were described and results were comparable to those obtained with delayed implant placement. Further long-term, randomized clinical trials are needed to give scientific evidence on the benefits of immediate implants over delayed implant

placement.”
“Three new glycosides, undatusides A-C (1-3), and 11 known compounds (4-14) were isolated check details from the flowers of Hylocereus undatus. Their structures were elucidated on the basis of spectroscopic data and chemical method.”
“The distribution of aldolase C (zebrin II)-positive and -negative Purkinje cells (PCs) can be used to define about 20 longitudinally extended compartments in the cerebellar cortex of the rat, which may correspond to certain aspects of cerebellar functional localization. An equivalent compartmental organization may exist in the deep cerebellar nuclei (DCN). This DCN compartmentalization is primarily represented by the afferent projection pattern in the DCN. PC projections and collateral nuclear projections of olivocerebellar climbing fiber axons have a relatively localized terminal arbor in the DCN.

In the first (forward) stage reflectance spectra corresponding to given instances of the parameter values were computed using Monte Carlo simulation of photon propagation through a multi-layered tissue. In the second (inversion) stage the parameter values were obtained via optimization using an iterated conditional modes algorithm based on Discrete Markov Random Fields. The method was validated on computer generated data contaminated with noise giving a mean normalized root mean square deviation (NRMSD) of 2.04. Validation on ex vivo images demonstrated

that parametric maps show gross correspondence with histological features of mucosa characteristic of cancerous, precancerous and noncancerous colon lesions. The key signs of abnormality were shown to be the increase in the blood volume fraction and LDK378 supplier decrease in the density of scattering particles.”
“This study was undertaken to investigate the herbicidal activity of mango (Mangifera indica L.) leaves against parthenium weed (Parthenium hysterophorus L.). The aqueous leaf extract at 15% concentration (on fresh weight basis) significantly

reduced germination, shoot length and the shoot and root biomasses of parthenium seedlings. In a leaf residue incorporation pot trial, 2% residue incorporation treatment significantly suppressed the root and shoot biomasses of parthenium, while a 5% residue treatment completely stopped the growth of the weed. Five flavonoids, namely ABT-263 cost (-)-epicatechin-3-O–glucopyranoside (1), 5-hydroxy-3-(4-hydroxyphenyl)pyrano[3,2-g]chromene-4(8H)-one (2), 6-(p-hydroxybenzyl)taxifolin-7-O–D-glucoside (tricuspid) (3), quercetin-3-O–glucopyranosyl-(1 2)–D-glucopyranoside (4) and (-)-epicatechin(2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H chromene-3,5,7-triol (5) were isolated from mango leaves. In a laboratory bioassay, 50 ppm solution of compounds 3 and 4 caused yellowing of the parthenium seedlings. A 250 ppm solution of compound 4 also significantly reduced germination and the root and Volasertib solubility dmso shoot lengths of parthenium seedlings. This study concludes that compound 4 exhibits herbicidal activity against parthenium

weed.”
“Ligularia achyrotricha (Diels) Ling has been used as a traditional Tibetan herbal medicine. Ligulachyroine A (1), a new twelve-membered macrocyclic pyrrolizidine alkaloid with a ketonic group located at C-3 and an hydroxy group linked at C-8, was isolated from the roots of L. achyrotricha. It is particularly noteworthy that the structure of 1 rarely appears in any other naturally occurring twelve-membered macrocyclic pyrrolizidine alkaloid reported to date. Three known lignans (2-4) and eight known coniferyl and sinapyl alcohol derivatives (5-12) were also obtained in this species. Their structures were elucidated through a careful analysis of their IR, MS, and NMR spectra. Compound 1 exhibited moderate activity against HL-60 and SMMC-7721 cells.

Partners may benefit from therapy where anxiety disorders are detected. Copyright (c) 2011 John Wiley & Sons, Ltd.”
“Recent studies demonstrated that diffusion tensor imaging (DTI) can provide information regarding white matter integrity of the corpus callosum (CC). In this study, DTI parameters were compared between cocaine dependent subjects (CDs) and non-drug using controls (NCs) in midsagittal CC. Fer-1 molecular weight DTI images were acquired from 19 CDs and 18 age-matched NCs. The midsagittal CC was segmented into: genu, rostral body, anterior midbody, posterior midbody, isthmus, and splenium. Linear mixed models analyses showed that, relative to NCs, CDs had lower fractional anisotropy (FA), higher radial diffusivity

(lambda(perpendicular to)) and higher mean diffusivity (D(m)) in the isthmus; higher X-L and D., in the rostra] body: and lower FA in the splenium. After including mass of lifetime alcohol use in the mixed model analysis of covariance (ANCOVA) as a covariate, significant between group differences in X, in the FOStral body and isthmus remained. These results Suggest that alterations in),, in the rostral body and isthmus were mainly due to cocaine use, consistent with previous studies showing that cocaine may alter myelin integrity. Between group differences in FA in the isthmus and splenium, and D, in the rostral body and isthmus became non-significant after inclusion

of alcohol use as a covariate. This is suggestive of alcohol influencing these values, or may be related to the decreased degrees of freedom for these effects. Consistent with clinical data of greater severity of drug use in smoked versus intranasal NSC23766 in vivo cocaine, subjects who smoked cocaine showed lower FA and higher lambda(perpendicular to) compared to intranasal CDs. (C) 2009 Elsevier Ireland Ltd. All rights reserved.”
“Deranged lipid metabolism is a common complication of chronic kidney disease (CKD). Uremia, and metabolic and endocrinological Fludarabine concentration disturbances associated with uremia, as well as the high prevalence of comorbidities,

wasting and inflammation in CKD patients, all play their role in promoting and modifying CKD-associated dyslipidemia. However, the exact pathomechanisms leading to lipid disorders are still poorly understood. Similarly, the impact of lipid disturbances on patient outcome is unclear. Many studies in dialysis patients have documented the, so called, ‘reverse epidemiology’, with low plasma cholesterol being an apparent risk factor for mortality. Potential explanations for this phenomenon include confounding by wasting and comorbidities, reverse causation, and also causal relationships with hypocholesterolemia having a direct impact on poor outcome. To elucidate the question of ‘reverse epidemiology’ some novel approaches have been introduced, for example, Mendelian randomization and time-dependent conditional survival analysis.

20) to -12 J/kg K (x=0.90). The adiabatic temperature changes measured for selected alloys in the series show a maximum value of 6 K when the magnetic field is changed from 0 to 5 T. (C) 2010 American Institute of Physics. [doi: 10.1063/1.3335590]“
“Tubular scaffolds demonstrated to be able to reconnect the proximal and distal stumps of transected peripheral nerves and induce regeneration of the lost nerve trunk. learn more Recently, a spinning technique has been developed, able to produce tubular collagen-based scaffolds characterized by a radially patterned microporosity. The technique is based on the centrifugal sedimentation of collagen

taking place when I cylinder, containing, all aqueous collagen suspension, is rotated rapidly around its axis. In

this work, the centrifugation process was modeled by means of the Lamm differential equation for collagen Concentration, with the assumption that sedimentation and diffusion coefficients Selleck PXD101 were dependent on the local concentration, according to appropriate scaling laws. With such assumptions, the model was able to predict the actual tube formation and its inner radius, ill good agreement with the experiment results. The possibility to predict the final scaffold inner diameter as a function of the processing parameters has a fundamental importance for the set LIP of a precise fabrication method, which does not make use of arty complex mold. This would significantly reduce the production complexity and the extent of scaffold manipulation during production, resulting in a cleaner production process and safety, of the device. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 116: 1879-1888, 2010″
“Background: Obesity is related to asthma, but factors influencing this relation have not been

clearly defined.

Objective: This study was designed to assess the role of eating behaviors and weight concerns in the association between obesity and asthma.

Design: A population-based sample of 11,710 adolescents, recruited from 186 secondary schools of 8 educational districts in France, completed a self-administered standardized questionnaire including DSM IV (Diagnostic and Statistical Manual of Mental Disorders) questions on eating disorders.

Results: Obesity (body mass index >= 95th percentile according to age and sex) was associated with asthma in girls (odds ratio: 1.48; 95% CI: 1.05, MLN4924 2.08) but not in boys (odds ratio: 1.07; 95% CI: 0.75, 1.54). Both obese and asthmatic adolescents were more likely to have abnormal eating behaviors and weight concerns (P < 0.05). In an adjusted polytomous logistic model with 4 categories based on the presence and/or the absence of asthma and obesity as the dependent variable, the odds ratio for weight concerns increased from a minimum value for asthmatic nonobese adolescents (odds ratio: < 1.5; P < 0.03) to a maximum value for asthmatic obese adolescents (odds ratio:> 6.3; P < 0.

(c) 2013 BioFactors 39(5):564-574, 2013″
“Magnetoencephalography (MEG) is increasingly used in the presurgical evaluation of pediatric seizure patients. Many pediatric patients require sedation or anesthesia to tolerate these exams. However, the available literature on anesthetic management in this population is very limited.

We retrospectively reviewed the records of all patients who underwent MEG scanning at our institution with regard to

the interaction of anesthetic management and quality of scan data.

High-dose propofol infusions (>= 200 mu g.kg(-1).min(-1)) were associated with high frequency artifacts that interfered buy Small molecule library with the identification of epileptiform discharges. Lower-dose propofol infusions (<= 100 mu g.kg(-1).min(-1)) did not produce artifacts but required co-administration of fentanyl to prevent patient motion. Dexmedetomidine infusions were not associated with signal artifacts and prevented patient motion very well in our initial patients and became

our standard technique.

In our experience, dexmedetomidine infusions are preferable to propofol-based techniques for pediatric MEG scans due to the absence Selleck Cyclopamine of adverse effect on interictal activity.”
“In the last years, the prevalence of HPV infection in the anal region has increased, especially in some groups like homosexual and HIV-positive people. Since this infection can be associated with the development of squamous anal cancer due to its progression from HPV infection to anal intraepithelial neoplasia (AIN) and finally to cancer, the screening and evaluation of these conditions are important. Anal cytology

and high resolution anoscopy are good methods that are available and can be used. Although useful, these Selleckchem GSK2879552 methods should be performed correctly and not indiscriminately in all patients. Patients for whom anal cytology screening is recommended are: HIV-infected patients, homosexuals, women who present with high-grade vulvar squamous intraepithelial neoplasia, vulvar cancer or cervical cancer. An abnormal anal cytology should be further evaluated with high resolution anoscopy.”
“The anti-cancer activity of organic selenium has been most consistently documented at supra-nutritional levels at which selenium-dependent, antioxidant enzymes are maximized in both expression and activity. Thus, there is a strong imperative to identify mechanisms other than antioxidant protection to account for selenium’s anti-cancer activity. In vivo work in dogs showed that dietary selenium supplementation decreased DNA damage but increased apoptosis in the prostate, leading to a new hypothesis: Organic selenium exerts its cancer preventive effect by selectively increasing apoptosis in DNA-damaged cells. Here, we test whether organic selenium (methylseleninic acid; MSA) triggers more apoptosis in human and canine prostate cancer cells that have more DNA damage (strand breaks) created by hydrogen-peroxide (H2O2) at noncytotoxic doses prior to MSA exposure.

79). In addition, for quinazoline substituents, estate contribution descriptors SsCH3E-index has a large deactivating effect.”
“A practice in wineries is to age wine in the presence of lysated lees instead of fresh lees, in order to reduce the time wine is conserved on lees and avoid possible microbiological and organoleptic risks caused by lees. Two treatments were used to induce lees lysis: acidification and acidification in combination with a mixture of beta-glucanases and pectinases. Acidification treatment in combination with enzymes induced significantly greater mannoprotein

and glucan release. The presence of lysated lees during wine storage in barrels produced wines with significantly different tannin contents. The ageing technique on lysated lees by acidification in combination with enzymes produced wines with more intense colors, lower luminosity and saturation, and a slight tendency towards red tones, 3-deazaneplanocin A solubility dmso and an increase in sweetness, fullness and mouth length. On the contrary, ageing technique on lysated

lees by acidification increased wine acid and fresh sensations. (C) 2010 Elsevier Ltd. All rights selleck reserved.”
“The optimal treatment of cutaneous leishmaniasis is controversial. We report our experience managing Old World cutaneous leishmaniasis in a pediatric refugee clinic. Conventional amphotericin B therapy caused reversible renal failure in 2 of 3 children treated. The choice of treatment for cutaneous leishmaniasis needs to balance the risks of treatment against the likely cosmetic benefits of therapy.”
“In an investigation of 4-amino-3,4-dihydronaphthalen-1(2H)-ones as novel modulators of allergic and inflammatory phenomena, we have

investigated a series of cyclic analogues. Tertiary amines of structural types 9, 10, 20 and 21 were synthesised and evaluated for mast cell stabilising activity. In vitro and in vivo studies showed that of these compounds, the cyclohexenylamino derivatives of tetralone and benzosuberone P505-15 datasheet of series 20 and 21 exhibited interesting activity both in vitro and in vivo.

[GRAPHICS]

.”
“An ultrasensitive electrochemical immunosensor based on nanogold particles (nano-Au), Prussian Blue (PB), polyaniline/poly (acrylic acid) (PANI (PAA)) and Au-hybrid graphene nanocomposite (AuGN) has been developed for the detection of salbutamol (SAL). Nano-Au, PB and PANI (PAA)-incorporated film was used to enhance the electroactivity, stability and catalytic activity for hydrogen reduction of the electrode. AuGN was used to immobilise chitosan, nano-Au and horseradish peroxidase-anti-SAL antibody (HRP-AAb). The resulting nanostructure (AuGN-HRP-AAb) was used as the label for the immunosensor. This is attributed to the high surface-to-volume ratio of graphene that allows the immobilisation of a high level of chitosan, nano-Au and HRP-Mb and its good electrical conductivity which can improve the electron transfer among HRP.

(C) 2010 Sociedad Espanola de Cardiologia.

Published by Elsevier Espana, S. L. All rights reserved.”
“With relatively low efficiency, differentiated cells can be reprogrammed to a pluripotent state by ectopic CA3 expression of a few transcription factors. An understanding of the mechanisms that underlie data emerging from such experiments can help design optimal strategies for creating pluripotent cells for patient-specific regenerative medicine. We have developed a computational model for the architecture of the epigenetic and genetic regulatory networks which describes transformations resulting from expression of reprogramming factors. Importantly, our studies identify the rare temporal pathways that result in induced pluripotent cells. Further experimental tests of predictions emerging from our model should lead to fundamental advances in our understanding of how cellular identity is maintained and transformed.”
“Introduction and objectives: Pharmacoinvasive strategy represents an attractive alternative to primary angioplasty. Using cardiovascular magnetic resonance imaging we compared the left ventricular outcome of the pharmacoinvasive strategy and primary angioplasty for the reperfusion of ST-segment elevation myocardial infarction.

Methods: Cardiovascular magnetic

Tozasertib Cell Cycle inhibitor resonance was performed 1 week and 6 months after infarction in two consecutive cohorts of patients included in a prospective university hospital ST-segment elevation myocardial infarction registry. During the period 2004-2006, 151 patients were treated with pharmacoinvasive strategy (thrombolysis followed by routine non-immediate angioplasty). During the period 2007-2008,

93 patients were treated with primary angioplasty. A propensity score matched population was also evaluated.

Results: At 1-week cardiovascular magnetic resonance, pharmacoinvasive strategy and primary AZD8055 in vitro angioplasty patients showed a similar extent of area at risk (29 +/- 15 vs. 29 +/- 17%, P = .9). Non-significant differences were detected by cardiovascular magnetic resonance at 1 week and at 6 months in infarct size, salvaged myocardium, microvascular obstruction, ejection fraction, end-diastolic volume index and end-systolic volume index (P > .2 in all cases). The same trend was observed in 1-to-1 propensity score matched patients. The rate of major adverse cardiac events (death and/or re-infarction) at 1 year was 6% in pharmacoinvasive strategy and 7% in primary angioplasty patients (P = .7).

Conclusions: A pharmacoinvasive strategy including thrombolysis and routine non-immediate angioplasty represents a widely available and logistically attractive approach that yields identical short-term and long-term cardiovascular magnetic resonance-derived left ventricular outcome compared to primary angioplasty. (C) 2010 Sociedad Espanola de Cardiologia. Published by Elsevier Espana, S. L. All rights reserved.

However, more pronounced pharmacokinetic differences were observed between the pregnancy and control subjects, with the 90% CI for the pregnancy: control ratio of geometric means for both total 0.68 (90% CI 0.57-0.81) and free AUC 0.78 (90% CI 0.63-0.95) not fully contained within the 0.66 – 1.50 interval. All subjects cleared parasites rapidly, and there was no difference in the percentage of women who were parasitaemic 12 hours after dosing.

Conclusions: A single dose of orally administered AS was found to be both effective and without adverse effects in this study of second and third trimester pregnant

women in the DRC. Although DHA AUC during pregnancy www.selleckchem.com/products/azd6738.html and postpartum were similar, the AUC for the pregnant group was less than the non-pregnant controls. The findings of this study suggest that additional studies on the pharmacokinetics of AS in pregnant women are needed.”
“Background: High dietary glycemic index (GI) and glycemic load (GL) may promote tumorigenesis by increasing endogenous concentrations of insulin-like growth factor I (IGF-I) or the bioavailability of estradiol. In vitro studies have shown that uterine leiomyoma (UL) cells proliferate in response to

IGF-I and display increased IGF-I gene expression and protein synthesis. Previous epidemiologic studies suggest that a high GL is a risk factor for endometrial and ovarian cancers, which, like UL, are hormone-responsive tumors.

Objective: We investigated the relation of dietary GI and GL with UL risk in the Black Women’s Health Study.

Design: In this prospective cohort study, Selleckchem Lapatinib Tubastatin A ic50 we followed 21,861 premenopausal women for incident UL from 1997 to 2007. Diet was assessed in 1995 and 2001 with food-frequency questionnaires. We used Cox regression to estimate incidence rate ratios (IRRs) and 95% CIs, controlled for potential confounders.

Results: During 162,604 person-years of follow-up, there were 5800 cases of UL diagnosed by ultrasound or surgery. Dietary GI was weakly associated with UL risk overall (IRR for highest

compared with lowest quintile: 1.09; 95% CI: 0.99, 1.19; P for trend = 0.04). Positive associations were observed between GL and UL in women aged <35 y (IRR for highest compared with lowest quintile: 1.18; 95% CI: 1.02, 1.37; P for trend = 0.15) and between GI and UL in college-educated women (IRR for highest compared with lowest quintile: 1.17; 95% CI: 1.03, 1.34; P for trend = 0.004).

Conclusions: Our results suggest that high dietary GI and GL may be associated with an increased UL risk in some women. The observed associations warrant investigation in future studies. Am J Clin Nutr 2010; 91: 1281-8.”
“The authors describe herein the magnetoencephalographic findings and long-term outcome of a girl with acquired opercular epilepsy with oromotor dysfunction. She presented with brief episodes of unconsciousness, tremulous movements of the upper limbs, and negative myoclonus, in addition to convulsive seizures.