Patients reported their pain improved after removal

of all sutures on the affected side. Patients with neuropathic pain did not differ from those without in regard to age, BMI, and preoperative prolapse stage, or in the number of sutures placed. None of the eight had recurrent pelvic organ prolapse (POP), with a median follow-up of 5 months.

CONCLUSION: Eight patients (1.6%) had postoperative neuropathic pain that resolved after all sutures were removed on buy PF-562271 the affected side. The removal of sutures was not associated with recurrent POP in the short-term. (Obstet Gynecol 2012; 120:292-5) DOI:10.1097/AOG.0b013e31826059f7″
“Sulfur mustard (SM) is a potent vesicant. The lack of an effective antidote makes SM a continued threat to both military and civilian settings. A surrogate agent, namely mechlorethamine (HN2), was used here to mimic the toxicity of SM, and the main objective of this study was to demonstrate if selected organoselenium analogs could protect cultured A-431 skin cells from HN2 toxicity. Test compounds included ebselen (EB-1) and three related organoselenium analogs (EB-2, EB-3 and EB-4). In the absence of test compound, a reproducible and robust cell death was observed in the cells following incubation with HN2 SRT2104 concentration (25 mu

M, 24 or 48 h) while cells treated with test compound alone (15, 30 or 60 mu M) for similar periods of time were generally not affected. When incubated in the presence of both HN2 and test compound for 24 or 48 h, it was found that EB-1, EB-2, EB-3 and EB-4 could spare the cells from death, with the EB-4 compound being the most effective at reducing HN2 toxicity. Light microscopy confirmed these findings. The organoseleniums were also examined for their effects on reducing lipid peroxidation in see more the A-431 skin cells. Among the test compounds, EB-4 reduced lipid peroxidation by HN2 to the greatest extent. These

studies, taken together, validate that the organoselenium antioxidants tested here may serve a purpose in the discovery of medical countermeasures to vesicants.”
“OBJECTIVE: To estimate the likelihood of cesarean delivery and length of labor in twin pregnancies undergoing induction of labor as compared with singleton pregnancies.

METHODS: This was a retrospective cohort study of 100 patients with twin pregnancy in one maternal-fetal medicine practice undergoing induction of labor from 2005 to 2012. The control group was 100 randomly selected patients in the same practice with a singleton pregnancy undergoing induction of labor over the same time period. The primary outcome was mode of delivery (vaginal or cesarean).

RESULTS: The likelihood of cesarean delivery did not differ between the groups (19% in twins compared with 21% in singletons, P=.724) nor did the time from induction to vaginal delivery (median and interquartile time 9.7 [5.5-12.5] hours in twins compared with 10.4 [6.6, 14.1] hours in singletons, P=.255).

In ten cases, death was attributed to circulatory collapse due to sepsis; severe pulmonary congestion and hemorrhage were present in these cases. The onset of fulminant bacterial infection depends on both virulence of the bacterium and status of the host defense system.”
“The aim of this retrospective study was to investigate factors affecting clinical pregnancy rates, especially age and duration of embryo

transfer, in IVF/intracytoplasmic sperm injection cycles (11313 embryo transfers). Overall clinical pregnancy rate was 30.0% (n = 394). Clinical pregnancy rates were found to be 31.6% for the <44 s interval, 25.9% for the 45-59 s interval and 23.6% for the >60 s interval (P = 0.020). AZ 628 order In the <35 year age group, clinical pregnancy rates were 35.1%, 29.9% and 30.6%, and in the >35 year age group, they were 26.9%, 21.0% and 13.4% (P = 0.013), respectively. According to logistic regression analyses, the odds of failed pregnancy increased by 1.61 times [95% confidence interval (CI) 1.07-2.41] for embryo transfer durations longer than 60 s and odds ratios of a failed pregnancy were 1.53 (95% CI 1.18-1.99) in the >35 year age group, 1.49 (95% CI 1.05-2.12) for fewer than learn more five oocytes and 3.38 (95% CI 2.10-5.43) for fewer than two transferred

embryos. In conclusion, to increase the likelihood of a successful pregnancy in women over 35 years of age, the duration of embryo transfer must be kept below 60 s. The number of oocytes obtained and the number of transferred embryos also play a role in the success of pregnancy. (C) 2009, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.”
“The aim of the present study was to assess changes of cell

membrane antigens on neutrophils in septic patients. Expression levels of neutrophil membrane antigens were measured employing a FACS calibur flow cytometer with several Bucladesine chemical structure fluorescence-labeled monoclonal antibodies. Expression levels of the CD14 antigen were higher in patients with sepsis than in healthy individuals. In particular, the expression levels of CD14 increased in patients complicated by septic shock. Expression levels of TLR-4 were higher in patients with sepsis or septic shock than in healthy individuals. Expression levels of CD11b and CD16 were lower in patients with sepsis or septic shock than in healthy individuals and were even lower in those complicated by septic shock. Expression levels of neutrophil membrane antigens in patients with sepsis markedly changed in the acute phase. However, these levels tended to return to those of healthy individuals in the convalescing phase. Analyses of the surface antigens on neutrophils strongly involved in biological defense or tissue injury are informative for understanding the pathology of sepsis and for conducting therapy targeting neutrophils in the future.

g., upper esophageal sphincter or anal sphincters). Recent impedance manometry investigations shed new light on the functional anatomy of the LES. These data corroborate a concept of this sphincter as a double-layer, twisted stretch sphincter. This sphincter requires tissue tension for optimal function. Retightening of the longitudinal stretch

of the esophagus provides an effective therapy if this tension is lost, e.g., for patients with hiatal hernias. Paralysis of the muscle selleck screening library fibers of this sphincter system results in functional obstruction, and this explains the pathophysiology of “”achalasia”".

Conclusions Based on available data, we propose a novel concept that better explains the structure-function relationship of the LES. Improved knowledge of the biomechanical factors of esophageal disorders can be expected to advance surgical treatment for these diseases.”
“CD83, a maturation marker for human and mouse dendritic cells (DCs), plays a critical role in CD4(+) T cell development as well as peripheral immune regulation. Here, two novel mouse anti-human CD83 monoclonal antibodies (MAbs) were prepared and their immunological characteristics were determined. Among the two MAbs, 8B4 binds to a linear epitope whereas 1E11 recognizes a conformational epitope. Cross-linking of 8B4 but not 1E11 with CD83-Ig

augments the fusion protein mediated inhibition of peripheral blood mononuclear cells (PBMCs). Thus the two MAbs may be good candidates for immunoassaying and functional exploration of CD83 molecule.”
“Objective: TPCA-1 datasheet To assess the association of the point-of-care hemoglobin A(1c) (POC A1C), fasting blood glucose (FBG), and BMI with fetal macrosomia and the need for medication in women with gestational diabetes (GDM).

Methods: POC A1C, FBG, and BMI values at GDM diagnosis and fetal weight at delivery were obtained for women identified from a prospective patient registry. These outcomes were compared between women who did not require medication

for GDM and women who did require medication.

Results: Mean values of POC A1C, FBG, and BMI RGFP966 in 67 patients who required medication were higher than those in 71 patients who did not require medication (POC A1C: 5.72 +/- 0.45% vs 5.35 +/- 0.46% [P<.001]; FBG: 97.4 +/- 12.3 mg/dL vs 86.4 +/- 9.5 mg/dL [P<.001]; BMI: 35.4 +/- 6.4 kg/m(2) vs 30.4 +/- 6.2 kg/m(2)[P<.001]). There was a modest correlation between POC A1C and FBG (Spearman rho 0.4, P<.001) and between POC A1C and BMI (Spearman rho 0.366, P<.001). Maternal POC A1C was not correlated with fetal weight at delivery (Spearman rho -0.010, P = .915).

Conclusions: Higher POC A1C, FBG, and BMI values were associated with the need for medication in women with GDM.

(C) 2011 American Institute of Physics. [doi:10.1063/1.3596827]“
“Despite a dramatic reduction in incidence and mortality rates, gastric cancer still remains one of the most common malignant tumors worldwide, especially in China. We sought to identify a set of discriminating genes that could be used for characterization and prediction of response to gastric cancer. Using bioinformatics analysis, two gastric cancer datasets,

GSE19826 and GSE2685, were merged to find novel target genes and domains to explain pathogenesis; we selected differentially expressed www.selleckchem.com/products/gw-4064.html genes in these two datasets and analyzed their correlation in order to construct a network. This network was examined to find graph clusters and related significant pathways.

We found that ALDH2 and CCNB1 were associated with gastric cancer. We also mined for the underlying molecular mechanisms involving these differently expressed genes. We found that ECM-receptor interaction, focal adhesion, PS-095760 and cell cycle were among the significantly associated pathways. We were able to detect genes and pathways that were not considered in previous research on gastric cancer, indicating that this approach could be an improvement on the investigative mechanisms for finding genetic associations with disease.”
“Objective. Study of radiographic features of maxillary BI 10773 GPCR & G Protein inhibitor sinusitis of odontogenic origin as visualized on 3-dimensional advanced imaging is essential for prompt diagnosis and appropriate management. This study attempted to describe and delineate radiographic characteristics of this condition.

Study design. Three cases of failed endodontic therapy presenting with confounding clinical signs and symptoms were subjected to

3-dimensional imaging with cone-beam volumetric computerized tomography (CBVCT) to evaluate changes in the maxillary sinuses.

Results. CBVCT showed varying involvement of the ipsilateral maxillary sinus in all 3 cases. The presentation varied from presence of intrasinus fluid to reactionary osseous response within the sinus.

Conclusions. CBVCT as a diagnostic aid to evaluate the involvement of the maxillary sinuses in cases of endodontic treatment failure seems to assist with formulation of a definitive diagnosis. Appropriate interventions may be instituted, including an otolaryngology consultation. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010;110:e53-e57)”
“We have epitaxially grown undoped beta-FeSi2 films on Si(111) substrates via atomic-hydrogen-assisted molecular-beam epitaxy. beta-FeSi2 films grown without atomic hydrogen exhibited p-type conduction with a hole density of over 10(19) cm(-3) at room temperature (RT).

The mechanisms by which prebiotics affect the immune system have not yet been investigated in detail. Most effects have been attributed to increases in the innate and acquired immune responses. This study was conducted to elucidate the long-term effects of orally administered lactulose on the immune response in the intestinal tract of probiotic-fed calves. Preruminant calves were randomized to 3 feeding

groups: milk replacer containing 1) no lactulose, 2) 1% lactulose, or 3) 3% lactulose. All 3 milk replacers contained 10(9) cfu Enterococcus faecium/kg. Messenger RNA expression of different this website cell activation markers, pro-and antiinflammatory cytokines, and IgA Fc receptor was investigated in the ileum, mesenterial lymph node, spleen, and white blood cells. A significantly greater number of blood lymphocytes were detected in the 3% lactulose group (P = 0.02) than in the control group. The expression results in male calves

indicated that the transcription of IgA Fc receptor in the ileal mucosa of the 1% lactulose treatment group increased significantly (P = 0.04) and also tended to increase in the 3% lactulose group (P = 0.07). Furthermore, decreases in IL-10 SB-715992 cell line and interferon-gamma mRNA expression were observed in the ileum (P = 0.04). The CD4-presenting lymphocytes were decreased significantly in the ileum (P = 0.04) and mesenteric lymph node (P = 0.01), whereas CD8-presenting lymphocytes were increased in the blood (P = 0.03) of females. Other proinflammatory cytokines (IL-1 beta, IL-8, and tumor necrosis factor-a) and antiinflammatory cytokines (transforming growth factor-alpha) did not show significant differences in mRNA expression among treatment groups. The results indicate that additional P505-15 lactulose feeding had an immunomodulatory effect on the composition of T-cell subsets in different immune compartments and

had minor effects on pro-and antiinflammatory cytokine mRNA expression.”
“We present the complex dielectric function of BiCrO3 thin films in the energy range of 0.73-9.8 eV determined using spectroscopic ellipsometry. By analyzing the absorption onset region, it is shown that the optical bandgap of BiCrO3 is indirect, with a value of 2.27 eV. The imaginary part of the BiCrO3 dielectric function, epsilon(2), calculated using density functional theory in the generalized gradient approximation with an Hubbard potential of 3 eV agrees well with the experimentally determined one. Raman spectra of both polycrystalline and epitaxial thin films of BiCrO3 are reported. The temperature dependent Raman measurements indicate a structural phase transition at similar to 400 K which was confirmed also by x-ray diffraction investigations. (C) 2011 American Institute of Physics. [doi:10.1063/1.

9 years (standard deviation [SD] = 12) had a median follow-up of 100 days (range 1-1007 days). In all cases, warm ischemia time Tubastatin A mouse was 0 minutes. Mean operative time was 143 minutes (SD = 59), and median estimated blood loss was 138mL (range 50-1500 mL). No intraoperative complications were encountered, and all surgical margins were negative. Our postoperative complication rate was 14.3%. At the most recent follow-up, the mean estimated glomerular filtration rate (eGFR) was 76.2mL/min/1.73m(2) (SD = 27.6), compared with 78.5mL/min/1.73m(2) (SD = 28.9) preoperatively (P = 0.11). Therefore, the mean eGFR decline of 2.3mL/min/1.73m(2) (SD = 9.1) was not significant.

Conclusions:

Off-clamp RAPN is associated with minimal morbidity and minimal decline in renal function on short-term follow-up. Further studies and continued monitoring of renal function are needed to determine if off-clamp RAPN provides any advantage in renal function preservation relative to the traditional RAPN with vascular clamping.”
“Emollients

are useful and important treatment adjuncts for patients with atopic dermatitis (AD). Heparinoid mucopolysaccharide creams or lotions are emulsion ointments for moisturizing the skin. The objective of this study was to investigate the view among adult AD patients regarding the effectiveness of emollients. We developed a questionnaire at our University Hospital to characterize how patients with AD viewed the efficacy of emollients. Patients were asked to participate eFT508 mw prior to treatment and the questionnaire was given selleck products within 1 month of treatment. The severity of AD was graded as mild, moderate, severe or very severe. The severity scoring was performed

only when the participants answered the questionnaire. Of the 110 enrolled AD patients, 103 returned the completed questionnaires. Ninety-eight patients (95.1%) used heparinoid mucopolysaccharide creams or lotions. There was a strong correlation between their view of the efficacy of the emollient and the condition of dry skin, pruritus and eczematous skin. There was a significant correlation between AD severity and the perceived efficacy of the emollient for dry skin, pruritus and eczematous skin. There was a greater sense of efficacy among patients with milder AD than in more severe AD cases. Patients who felt sufficient efficacy of the emollient for pruritus were significantly older than those who felt there was no efficacy. In addition, the age of onset of AD was significantly higher among those who felt sufficient efficacy for pruritus compared to those who felt little efficacy. We speculate that the efficacy of emollients could be demonstrated in the treatment of milder AD, but may only have partial efficacy in more severe cases. Emollient therapy might have lower efficacy for pruritus among younger or earlier onset AD patients.

“
“Radiotherapy (RT) is often employed in patients with acromegaly TPCA-1 cost refractory to medical and/or surgical interventions in order to prevent tumour regrowth and normalize elevated GH and IGF-I levels. It achieves tumour control and hormone normalization up to 90% and 70% of patients at 10-15 years. Despite the excellent tumour control, conventional RT is associated with a potential risk of developing late toxicity, especially hypopituitarism, and its role in the management of patients with GH-secreting

pituitary adenomas remains a matter of debate. Stereotactic techniques have been developed with the aim to deliver more localized irradiation and minimize the long-term consequences of treatment, while improving its efficacy. Stereotactic irradiation can be given in a single dose as stereotactic radiosurgery (SRS) or in multiple doses as fractionated stereotactic radiotherapy (FSRT). We have reviewed the recent published literature on stereotactic techniques

for GH-secreting pituitary tumors with the aim to define the efficacy and potential adverse effects of each of these techniques.”
“Early brain injury occurs in newborns with congenital heart disease (CHD) placing them at risk for impaired neurodevelopmental outcomes. Predictors for preoperative brain injury have not been well described in CHD newborns. This study aimed to analyze, retrospectively, brain magnetic resonance imaging (MRI) in a heterogeneous group of newborns buy PD98059 who had CHD surgery

during the first month of life using a detailed qualitative CHD MRI Injury Score, quantitative imaging assessments (regional apparent diffusion coefficient [ADC] values and brain volumes), and clinical characteristics. Seventy-three newborns who had CHD surgery at 8 +/- A 5 (mean +/- A SD) days of life and preoperative brain MRI were included; 38 also had postoperative MRI. Thirty-four (34 of 73, 47 %) had at least one type of preoperative brain injury, and 28 of 38 (74 %) had postoperative brain injury. The 5-min APGAR score was negatively BAY 63-2521 associated with preoperative injury, but there was no difference between CHD types. Infants with intraparenchymal hemorrhage, deep gray matter injury, and/or watershed infarcts had the highest CHD MRI Injury Scores. ADC values and brain volumes were not different in infants with different CHD types or in those with and without brain injury. In a mixed group of CHD newborns, brain injury was found preoperatively on MRI in almost 50 %, and there were no significant baseline characteristic differences to predict this early brain injury except 5-min APGAR score. We conclude that all infants, regardless of CHD type, who require early surgery should be evaluated with MRI because they are all at high risk for brain injury.

In a randomised controlled setting, 174 CC-resistant infertile PCOS women were randomized into two parallel groups; Group I received CC 100 mg/day for 5 days plus uFSH 37.5 IU/day while group II received only uFSH 37.5 IU /day. Subsequent increments of uFSH by 37.5 IU/day this website were made according to response. Primary outcome was ovulation rate. Secondary outcomes were clinical pregnancy rates, number of follicles, endometrial thickness, and gonadotropins consumption.

Our results have demonstrated that group I compared to group II had

significantly higher ovulation rate per intention to treat [ITT] [72.4 % vs. 34.2 %, p < 0.001]. Clinical pregnancy and live birth rates were comparable between the two groups. Group I consumed significantly lower total FSH dose and needed significantly shorter stimulation duration compared to group II.

CC co-administered during low dose HP uFSH versus uFSH for CC-resistant PCOS yields significantly higher ovulation rate and less consumption of FSH.”
“Despite more than 30 years of clinical use, questions remain

about the safety of xenon gas in Xenon-CT cerebral blood flow (XeCTCBF) studies. In particular, xenon’s effect on brain oxygen (PbtO(2)) in comatose patients is not well defined. Our objective ATM Kinase Inhibitor manufacturer was to assess the effect of a 4.5-min inhalation of 28 % stable xenon on several physiologic variables, including intracranial pressure (ICP), cerebral perfusion pressure (CPP), and PbtO(2) in comatose patients (Glasgow Coma Scale [GCS] a parts per thousand currency signaEuro parts per thousand BTSA1 8). Thirty-seven comatose patients who underwent 73 XeCTCBF studies were identified retrospectively from a prospective observational database. Changes in MAP, HR, SaO(2), EtCO2, ICP, CPP, and PbtO(2) measured at the start of xenon administration and every minute for 5 min thereafter were assessed. The maximum change in each variable also was determined for each scan to tabulate clinically relevant changes. Statistically, but not clinically significant changes in MAP, HR, and EtCO2 were seen. Xenon had no effect on ICP, and a small, but clinically insignificant decrease

in CPP and PbtO(2), was observed. There was a varied response to xenon in most measured variables. Clinically significant changes in each were infrequent, and readily reversed with the cessation of the gas. We conclude that xenon does not appear to have a clinically significant effect on ICP, CPP, and PbtO(2) and so appears safe to evaluate cerebral blood flow in comatose patients.”
“OBJECTIVE: This study was performed to determine the effect of the tocotrienol-rich fraction on the lifespan and oxidative status of C. elegans under oxidative stress.

METHOD: Lifespan was determined by counting the number of surviving nematodes daily under a dissecting microscope after treatment with hydrogen peroxide and the tocotrienol-rich fraction.

(C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci 122: 1599-1606, 2011″
“The contribution IPI-549 of carrier tunneling and gate induced drain leakage (GIDL) effects in the total gate and drain currents of FinFET devices with different dimensions is analyzed. In order to fulfill this task, expressions for the leakage current due to

carrier tunneling and GIDL effects at a Metal-Dielectric-Semiconductor structure were established and incorporated in the Symmetric Doped Double-Gate Model (SDDGM) for metal-oxide-semiconductor field-effect transistors (MOSFET). It is shown that both phenomena have to be taken into account for precise modeling of the device in all the operation regions although GIDL current can become predominant in the subthreshold region. The dependence of gate tunneling current in inversion and subthreshold regimes of operation is modeled as function of the applied voltages and transistor physical parameters by using analytical expressions. The present leakage current model is validated by comparing Selleckchem Geneticin modeled with measured total gate and drain

currents for FinFETs with different dimensions. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3575324]“
“New poly(ether ether ketone)s and poly (ether ether ketone ketone) s were synthesized by polycondensation of each of the three bisphenols, viz., 4,4′-(octahydro-2(1H)-naphthylidene) bisphenol, 4,4′-(octa-hydro-2(1H)-naphthylidene) bis-3-methylphenol, and 4,4′(octahydro-2(1H)-naphthylidene) bis-3,5-dimethylphenol with 4,4′-difluorobenzophenone

and 1,3-bis(4-fluorobenzoyl) benzene in Selleck MM-102 a mixture of N,N-dimethylacetamide and toluene [1 : 1 (v/v)] in the presence of anhydrous potassium carbonate. Inherent viscosities of poly(ether ether ketone) s and poly (ether ether ketone ketone) s were in the range 0.32-0.80 dL/g and number-average molecular weights were in the range 16,100-55,900 g/mol. Poly(ether ether ketone) s and poly(ether ether ketone ketone) s were soluble in organic solvents such as dichloromethane, chloroform, tetrahydrofuran, meta-cresol, pyridine, and 1-methyl-2-pyrrolidinone at room temperature and could be cast into tough, transparent, and flexible films from their chloroform solutions. Wide angle x-ray diffraction measurements revealed the amorphous nature of poly(ether ether ketone) s and poly (ether ether ketone ketone) s. The glass transition temperature poly(ether ether ketone) s and poly(ether ether ketone ketone) s were in the range 185-251 degrees C. The temperature at 10% weight loss, determined from thermogravimetric analysis, of poly(ether ether ketone) s and poly(ether ether ketone ketone) s in nitrogen atmosphere was in the range 462-493 degrees C indicating their good thermal stability. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci 122: 1607-1613, 2011″
“Several postpartum neurologic injuries have been described in detail, while obturator nerve injuries are rarely reported.

The raw material was treated under non-isothermal conditions (150-240 degrees C) and the effects on the composition of both liquid and solid phases were evaluated.

The yields and composition of the solid fraction and soluble products are presented and interpreted using the

severity factor (log R-0). The operational conditions for the maximum yield of xylo-oligosaccharides (XOS) of 53% of initial xylan, were established buy KPT-8602 for log R-0 of 3.75. Under these conditions 72% of xylan was hydrolysed while cellulose and lignin were not substantially affected although an increase in the enzymatic digestibility of cellulose was attained. For the severest condition (log R-0 =4.51) the solids contained 61.7% glucan and 31.0% lignin.

The XOS rich liquors and the glucan and lignin enrichment of the solid phase make corn straw a suitable raw material in a biorefinery framework and the hydrothermal treatment a favourable first step in the processing. (C) 2013 Elsevier B.V. All rights reserved.”
“Obesity is a risk factor for female pelvic floor

disorders. The study objective was to determine whether AZD5153 clinical trial there was a difference in the subjective reporting of pelvic symptoms before and after bariatric surgery.

This was a prospective cohort study of female patients that underwent bariatric surgery. Patients completed a demographic questionnaire, the Pelvic Floor Distress Inventory-20 (PFDI-20), and the Pelvic Floor Impact Questionnaire-7 (PFIQ-7) before surgery and at 6 and 12 months following surgery. Body mass index (BMI) was compared between time points using Student’s t tests (P < 0.05 significant). Symptom and impact on quality of life prevalence were compared using McNemar’s test and questionnaire scores were compared using the Wilcoxon matched pairs test (P < 0.025 significant).

At 12 months after surgery, 63 patients had completed the study. Even with significant weight loss (BMI, 43.7 kg/m(2) to BMI, 29 kg/m(2);

P < 0.001), there was no significant difference in the prevalence of pelvic floor symptoms before and after surgery (94% to 81%, P = 0.2). Prevalence of pelvic floor symptom impact on quality JQ1 research buy of life did significantly decrease after surgery (56% to 30%; P = 0.004). Baseline PFDI-20 and PFIQ-7 scores were low; however, there was still a significant reduction in PFDI-20 and PFIQ-7 scores after surgery (P < 0.001).

Prevalence of pelvic floor symptoms did not vary greatly after surgery; however, significant weight reduction did improve the degree of bother and quality of life related to these symptoms.”
“Background: There is growing interest in theory-driven, qualitative and mixed-method approaches to systematic review as an alternative to (or to extend and supplement) conventional Cochrane-style reviews.