Worsening of the mean CBCL Aggressive Behavior score occurred for

Worsening of the mean CBCL Aggressive Behavior score occurred for LEV but not placebo, leading to similar results for Externalizing Syndromes and Total Problems (all P<0.05 vs placebo). The change in the CBCL Activities Competence 3-MA mw score favored LEV (P<0.05). These results are in line with the known safety profile of LEV. (C) 2010 Elsevier Inc. All rights reserved.”
“Actual and potential applications of metallic cobalt rely on its crystal size-and phase-dependent magnetic properties. On this basis, the

present work addresses the synthesis and characterization of nanocrystalline cobalt particles produced through a modified polyol-based approach, which is conducive to the formation of epsilon (epsilon-Co) or hcp-Co phases. Metastable epsilon-Co could be converted into hcp-Co by controlled additions of polyvinyl pirrolidone (PVP) in trimethylene-glycol. XRD evidenced the progressive conversion of the APR-246 epsilon-Co phase into the hcp-Co phase, as the PVP/Co mole ratio increased from 0 to 11. Magnetic measurements confirmed the strong influence of synthesis conditions on crystal structure and hence, on magnetic properties; the coercivity of the products varied from 134 Oe for epsilon-Co to 752 Oe for the hcp-Co. These values agreed with the soft magnetic nature of epsilon and hard

magnetic character of hexagonal phases of cobalt. (C) 2011 American Institute of Physics. [doi:10.1063/1.3562450]“
“The aggregation and accumulation of the microtubule-associated protein (Tau) is a pathological hallmark of Alzheimer disease (AD) and many neurodegenerative diseases. For a long time research has focused on neurofibrillary tangles (NFTs) and other large meta-stable

PND-1186 Angiogenesis inhibitor inclusions composed of aggregated hyperphosphorylated tau protein. The correlation between these structures and disease progression produced conflicting results; moreover, the mechanism of their formation remains poorly understood. Lately, the significance and toxicity of NFTs have been challenged and a new aggregated tau entity has emerged as the true pathogenic species in tauopathies and a possible mediator of A beta toxicity in AD; specifically, aggregates of a size intermediate between monomers and NFTs the so-called tau oligomers. Tremendous efforts have been devoted toward the optimization of a safe vaccine for AD by targeting A beta peptide; despite the disappointing results, these studies produced a wealth of useful knowledge, which should be considered in developing tau-based immunotherapy. Herein, we discuss the evidence supporting the critical role of tau oligomers in AD, the potential and challenges for targeting them by immunotherapy as a novel approach for AD treatment.

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