We thank Matt Kleinman for his help in collecting Ion Channel Ligand Library mw the data and Drs. Anouk Scheres, James Rilling, and Lynn Nadel for their helpful comments. We would like to acknowledge funding from the National Institute of Aging (R21AG030768) to A.G.S., the

National Institute of Mental Health (R03MH077058) to A.G.S. and (F31MH085465) to L.J.C., and the National Science Foundation to M.D. “
“In this issue of Neuron, we present a series of Reviews and Perspectives on neural stem cells and neurogenesis. The study of neural stem cells (NSCs) has provided fundamental insight into how the exquisite diversity of neurons and glia in the nervous system is achieved. And the role of NSCs does not end with development. While it was once thought that the production of neurons ends early in life and the adult brain has little potential for regeneration, the discovery of adult neurogenesis radically changed this

view. We now know that neurogenesis occurs throughout life, giving us hope that this regenerative potential might be harnessed for the development of therapies for neurological Nutlin-3a price disorders. Given that this is such an active area of research, it wasn’t possible to cover the full spectrum of the field in a single issue. Our goal was to highlight a range of topics and some of the conceptual themes that have emerged from recent work. These Reviews and Perspectives discuss how the study of NSC biology and adult neurogenesis has provided fundamental insight into brain development and function. The potential clinical implications of this work are also considered. One of the central debates in the field is the focus of a pair of Point/Counterpoint pieces by Rene Hen and colleagues and Fred Gage and colleagues. In these pieces, the authors discuss their distinct views of the role of adult born neurons in cognition. In either addition, this collection also contains two NeuroViews that look at stem cell research from a global and societal perspective. In his piece

Douglas Sipp, from the RIKEN Center for Developmental Biology, discusses how stem cell research is a global enterprise, commenting on the resources and challenges for stem cell researchers across the globe. In the second NeuroView Patrick Taylor, Chair of the ISSCR Task Force on Unproven Stem Cell Treatments, considers how active engagement between scientists and the public, as well as ethicists and the government, has transformed the landscape of stem cell research. In their May issue, our colleagues at Cell Stem Cell published a special collection of Reviews and research papers on NSCs. The Neuron and Cell Stem Cell articles provide a complementary view of the NSC field. We were excited to collaborate with Cell Stem Cell on this project and hope that our goal of highlighting the intersection between the neuroscience and stem cell communities has been realized.