Via duodenotomy, the bleeding vessel can be seen on the floor of the ulcer and can be rapidly oversewn; then the duodenotomy is closed normally with horizontal sutures to avoid stenosis and without need of routine pyloroplasty. A Billoth-1 resection with distal gastrectomy might be needed if D1 is fully shattered by a large duodenal ulcer. Surgical hemostasis or angiographic embolization (where readily available) should be performed only after endoscopic failure. Open surgery

is recommended when endoscopic treatments failed and there is evidence of ongoing bleeding +/− hemodynamic instability. Peptic ulcer bleeding in patients receiving anti-thrombotic therapy Patients on antiplatelets or anticoagulant therapy with acute UGIB represent a major challenge and need to Lazertinib clinical trial be managed on a individual basis and the best way to treat patients on antithrombotic drugs with acute UGIB is clinically challenging. These patients are of course at high risk of thromboembolism buy Rigosertib because of their underlying

cardiovascular illness. However, discontinuation of anti-thrombotic therapy may be necessary to control bleeding or prevent rebleeding. A multidisciplinary and individualized evaluation is needed to decide either to stop or to resume anti-thrombotic, balancing thromboembolic risk against the risk of bleeding. In a randomised trial of continuous versus discontinued aspirin treatment in patients with PUB and high cardiothrombotic risks, those receiving continuous aspirin had a twofold increased risk of early recurrent bleeding (10,3% vs. 5,4% at day 30) but a tenfold reduced risk of mortality (1,3% vs. 10,3% at 8 weeks) compared with those remained without aspirin [137]. In patients at low risk of recurrent

bleeding, aspirin can be resumed the after-bleeding morning. The antiplatelet effect of aspirin lasts for about 5 days and the risk of early recurrent bleeding is high in the first 3 days; thus, in high-risk cardiovascular patients, it might be reasonable to resume aspirin on fourth day after bleeding to minimise both bleeding and thrombotic risks [94]. Patients on dual antiplatelet treatment (e.g. aspiring and clopidogrel), especially after recent placement of Selinexor ic50 drug-eluting coronary stents, are at high Histone demethylase risk of thrombosis. In patients at low risk of recurrent bleeding, dual antiplatelet treatment should be continued. In those at high risk, cessation of both antiplatelet drugs should be avoided, given the very high risk of stent occlusion [138]. In high-risk patients, after endoscopic control of bleeding, high-dose PPIs infusion and temporarily withholding of clopidogrel is recommended. Early resumption of clopidogrel should be considered in patients who had stent placement within 4 weeks, left main stem disease, and known coronary artery dissection [94]. Major gastrointestinal bleeding is often associated with anticoagulant therapy. Rapid correction of the coagulopathy is recommended.