The resection was complete in 72 (85 %) patients, incomplete (ICR) in seven (8 %) and six (7 %) patients did not undergo surgery. Fifty-five patients were administered neoadjuvant and 61 were administered adjuvant chemotherapy (high-dose,
n = 50). The OS (5 year) was 68 %: stage 1 (100 %), 2 (90 %), 3 (77 %), 4 (52 %), 4S (80 %) and high-risk NB (52 %). The OS in high-risk NB patients was correlated with a good chemotherapeutic response of the primary tumour, with Belnacasan a RR for mortality = 0.3 (95 % CI 0.1-0.7; p = 0.01), but not with the CR, which had an RR = 0.9 (95 % CI 0.3-2.4; p = 0.84). The OS in high-risk NB patients was related to a good histological chemotherapeutic response, but not with complete excision of the primary tumour.”
“Short sleep duration has recently been found to be associated with obesity in children, but findings involving adolescents have been less consistent, and some have mentioned gender differences. To investigate the association between parent-reported sleep duration and adiposity in early adolescence (10-12 years old) and to explore gender differences within this population. Participants were 1309 fifth-grade students (685 boys) from 10 primary schools in Shanghai, China. Body mass index (BMI), waist-height ratio (WHeR) and body fat percentage (BF%) were assessed. Sleep and other potential contributors were recorded by parents or self-reported. Compared with adolescents in the longest sleep group
(greater than or equal to Selleckchem GSK690693 +1 SD, a parts per thousand yen10.05 h), those in the shortest sleep group (less than -1 SD, smaller than 8.89 h) had significantly higher BMI, WHeR and BF%. Sleep was found to be closely related to increased adiposity in girls who were in the shortest and shorter sleep group ( smaller than mean, smaller
than 9.45 h). No association was found in boys. Short sleep duration was associated with higher adiposity indices in early adolescents from China, especially in girls. Interventions focusing on modifying adolescents’ sleep habits may potentially prevent obesity and overweight.”
“Whole-comparative genomic Etomoxir supplier hybridization (W-CGH) allows identification of chromosomal polymorphisms related to highly repetitive DNA sequences localized in constitutive heterochromatin. Such polymorphisms are detected establishing competition between genomic DNAs in an in situ hybridization environment without subtraction of highly repetitive DNA sequences, when comparing two species from closely related taxa (same species, sub-species, or breeds) or somewhat related taxa. This experimental approach was applied to investigating differences in highly repetitive sequences of three sheep breeds (Castellana, Ojalada, and Assaf). To this end, W-CGH was carried out using mouflon (sheep ancestor) chromosomes as a common target to co-hybridize equimolar quantities of two genomic DNAs obtained from either Castellana, Ojalada or Assaf sheep breeds.