The infections can spread rapidly, frequently leading to nosocomial episodes which can be dangerous. Studies conducted in Asia estimate that the incidence rate in elderly persons to be 15?C40%, which can be equal to or greater than that of Haemophilus inuenzae Factor Xa and the events are far more common in Asia than elsewhere. Even though the situations of community acquired K. pneumoniae has obviously diminished, the mortality rate remains signicant because of this of other underlying disease that tend to be strongly within the affected patient including alcoholics despite optimal medical treatment. These quick situations deserved to be recognized, examined and delineated. Lately, genome sequencing determination for the whole genome of K. pneumoniae MGH 78578 was completed in 2007 by Genome Research Center of Washington University of St. Louise. It contains about 5 million of nucleotides price BI-1356 and a complete of 4,894 genes and out of that, 4,776 genes encode proteins. Further analysis indicated that from the 4,776 protein coding genes, there are about 20% of the genes which are annotated badly and are classi?ed as hypothetical genes. The theory is that, these hypothetical genes are ultimately translated into proteins referred to as hypothetical proteins. Additionally, these hypothetical proteins haven’t shown to exist by experimental protein research. They also normally have low sequence identity to known annotated proteins and most of the practical facet of these proteins aren’t known. It is for that reason worth to estimate their structures which give clues to the characteristics of these proteins in the view of the fact that they are coded by 20% of genes in the genome of E. pneumoniae. In this study we aimed to interrogate and analyze these proteins via computational approach to give insight to us of their possible function and components. There are certainly a total of 1,003 hypothetical proteins in K. pneumoniae MGH 78578, of which one that is the concentration of our discussion has been assigned as KPN00728. Recently, a modification Endosymbiotic theory of the genome map of this organism given the event of KPN00729 as provisionally Chain D of Succinate dehydrogenase. as hypothetical proteins once we started this work, this protein along with KPN00728 were classi?ed. To time, even though function of KPN00729 is provisionally known, the design with this protein is yet to be established. KPN00728 and KPN00729 have 91 and 115 proteins, respectively. BLAST result showed that both of them have significantly more than 90% sequence identity with Succinate dehydrogenase of Enterobacteriaceae family. As it is assumed that the event of a not known protein natural product library can be inferred from other known homologous proteins centered on their sequence and structure similarity, for that reason, we postulated that these hypothetical are subunits of Succinate dehydrogenase enzyme. Succinate dehydrogenase plays an essential role in the aerobic respiratory chain and Krebs cycle in equally eukaryotic and prokaryotic organisms. Generally speaking, it’s secured by four different genes namely SdhA, SdhB, SdhC and SdhD, respectively. It is believed that the mutation of human genes coding Succinate dehydrogenase subunits results in aging and cancer although this rarely happen. Nevertheless, no information on this process have already been described up to now.