The conditioning regimen used in all cases consisted of high-dose of busulfan and melphalan. Median age at transplantation was 3 years (range: 0.7–14 years). The median times to neutrophil and platelet engraftment were 11 days (range: 9.16 days) and 13 days (range: 9.33), respectively. Twenty-one patients developed nonhematologic toxicity: 15 patients had mucositis, 4 patients developed an engraftment syndrome, and there were 2 cases of liver toxicity. No toxic deaths were observed. There were 15 patients who relapsed. The median time to relapse was 6 months

after the transplant (range: 3–13 months). With a median follow-up of 55 months (range: 4–180 months), the PFS was 57%% +/-+/- 8.5%% for the whole group. In multivariate analysis,

age below 3 years (P < .005), complete remission (CR) pretransplantation (P < .07) BKM120 datasheet and 1p germline status (P < .01) were variables associated with better outcomes. Patients who were or achieved early CR following transplantation (3 months posttransplantation) had a probability of PFS of 91%% +/-+/- 6%% as compared to patients who did not (PFS 9%% +/-+/- 8%%) (P < .0001). This retrospective study shows that high dose of busulfan and melphalan as conditioning regimen in children with high-risk neuroblastoma is associated with very low morbidity and no mortality in the authors” hands. Younger patients with no 1p deletions and in first CR at transplantation had the better outcome.</.”
“In this paper we report high magnetic field (-140 <= H <= 140 kOe) magnetization G418 purchase data for cobalt ferrites (crystallites size similar this website to 42 nm) for temperatures (T) varying from 5 to 340 K. The T-dependence for the cubic magnetocrystalline anisotropy constant K-1 was determined by using the “”law of approach”" (LA) to saturation. The values of K-1 were found to be substantially different from previously reported values obtained using the same procedure but with H up to 50 kOe. By properly choosing the quantum parameters we found

a very good agreement between the values calculated by using the model proposed by Tachiki [Prog. Theor. Phys. 23, 1055 (1960)] and the K-1 versus T data. For instance, the values of K-1 measured (calculated) for 5 K and 340 K were 28.3 x 10(6) erg/cm(3) (27.7 x 10(6) erg/cm(3)) and 7.4 x 10(6) erg/cm(3) (6.8 x 10(6) erg/cm(3)), respectively. The values of the parameters used to fit the data in both magnetic field regimes were chosen based on cation distribution over the A and B-sites on the spinel structure of the nanoparticles. (C) 2011 American Institute of Physics. [doi:10.1063/1.3626931]“
“The dynamic structuring of natural rubber (NR) was studied selecting two specific Hevea brasiliensis genotypes (RRIM600 and PB235) to prepare model samples. The mesostructure (macromolecular structure + aggregates or gel) of NR samples was studied by SEC-MALS.