She had not previously seen an ophthalmologist and had no history suggestive of trauma, surgery, red eyes, or pain. No systemic illnesses were reported. She was born at home; no additional birth history was available. Family and social histories were noncontributory. selleckchem Inhibitors,Modulators,Libraries On examination, visual acuity was hand movements in both eyes. Intraocular pressures were 14 mm Hg in the right eye and 17 mm Hg in the left. The eyes were orthophoric, Inhibitors,Modulators,Libraries with full extraocular motility. Slit-lamp biomicroscopic examination was remarkable for whitish membranous structures in the anterior chambers of both eyes that appeared to be empty capsular bags located in the lower part of the anterior chambers ( Figures 1, 2A, 3A). No residual zonules or signs of inflammation were evident. The pupils were 3�C4 mm and reacted to light sluggishly.

Both eyes were aphakic; an intact anterior vitreous face was present. The optic discs of both eyes were hypoplastic and pale ( Figures Inhibitors,Modulators,Libraries 2B, 3B, , 4, 4, , 5 5). Figure 1 Anterior segment photograph of the right eye (A) and left eye (B) showing the empty capsular bag in the anterior chamber. Figures 2 Slit-lamp photograph of the right eye (A) and the left eye (B) showing the anterior chamber location of the capsular bag. Figure 3 Photograph of the right eye (A) and left eye (B), pupil dilated. Figure 4 Retinal photograph of the right eye showing pale optic disc and sheathed vessels. Figures 5 Fundus photograph of the left eye showing changes similar to those observed in the right eye. The patient was sent for refractive correction, but her vision failed to improve beyond hand movements in both eyes.

Her refraction was +10.00 +3.50 �� 55 in the right eye and +11.00 +2.50 �� 108 in the left. Routine blood tests, including full blood count, fasting blood sugar, erythrocyte sedimentation rate, blood urea, and serum electrolytes and creatinine, were normal. Testing for congenital infections, including Inhibitors,Modulators,Libraries toxoplasmosis, rubella, cytomegalovirus, leptospirosis, and herpes simplex virus were also performed and found to Inhibitors,Modulators,Libraries be negative. Computed tomography of the brain and orbits with contrast agents revealed no abnormalities. Discussion Our patient was initially assumed to have a uveitic disorder, largely based on fundus findings. Couching was also suspected, but there was no history suggestive of such an intervention.

Exhaustive investigations Entinostat have been unable to prove any secondary causes for this condition to have occurred in this patient. Spontaneous absorption of cataracts or clear lenses is rare. Marlow��s review of the literature and his own cases estimated the prevalence of this condition to be one case reported annually.1 Rathinam et al2 reported that 18.5% of eyes with leptospirosis had spontaneous absorption of cataract. This is the first case of spontaneous lens absorption we have encountered in our clinical practice. Spontaneous cataract absorption was first reported by GH Warnatz in 1835.