S. Methods: We conducted a retrospective cohort study using population-based national data from the United Network for Organ Sharing registry to evaluate the impact of diabetes on long term survival following SLKT among U.S. adults from 2003 to 2012. Post-SLKT

survival was evaluated with multivar-iate Cox proportional hazards model adjusted for age, sex, hepatitis C virus infection, body mass index, race/ethnicity, PD0325901 in vitro hepatocellular carcinoma, ascites, hepatic encephalopathy, Model for End-stage Liver Disease (MELD) score, and cardiac disease. Results: Overall, 2,782 adult patients underwent SLKT from 2003-2012, including 933 diabetic (33.5%) and 1,849 non-diabetic (66.5%) patients. In the multivariate Cox proportional hazards model, patients with diabetes mellitus had significantly lower post-SLKT survival than patients without diabetes mellitus (HR 1.34, 95% CI, 1.13 – 1.58, p<0.001). Conclusions: In the U.S. experience, pre-transplant diabetes mellitus was an independent predictor of lower survival following SLKT. Disclosures: Aijaz Ahmed - Consulting: Bristol-Myers Squibb, Gilead Sciences Inc., Roche, AbbVie, Salix Pharmaceuticals, Janssen pharmaceuticals, Vertex Pharmaceuticals, Three Rivers Pharmaceuticals; Grant/Research Support: Gilead Sciences Inc. The following

people have nothing to disclose: Ryan B. Perumpail, Robert Wong, Andrew M. Su, Jane Tan, John Scandling BACKGROUND:Suspicious findings of biliary obstruction on allograft histology often prompt an ERCP for further evaluation in OLT recipients ACP-196 concentration with cholestatic liver test abnormalities. No study has systematically evaluated histological correlates of anastomotic biliary strictures in OLT recipients to provide guidance or support for this approach. AIM: Retrospective evaluation of liver Oxymatrine biopsy performed within 1 week of ERCP in recipients of OLT with confirmed biliary strictures. METHODS: Records of 806 adult liver transplant recipients, age > 18, who underwent OLT at the Methodist

University Hospital Transplant Institute between April 6, 2006 and December 31, 2012, were reviewed. Patients with PSC (n=24), and/or non-anas-tomotic biliary stricture (n=10) were excluded. 25 recipients with new or clearly defined recurrent ABS on ERCP with liver biopsy performed within 1 week of ERCP were included. RESULTS: Most prominent liver histology findings in recipients with ABS included mononuclear portal inflammation (88%), feathery degeneration of the hepatocytes (64%) and periportal ductular reaction (52%). Moderate to marked mononuclear inflammation was noted 36%, but portal neutrophilic infiltrate is less commonly noted (24%). Cytological alteration of chol-angiocytes, cholestasis, canalicular bile plugs each occurs in about 1/3rd of the recipients with ABS. Definite bile duct loss is an uncommon, noted in 8% of recipients. Periportal interface activity, if noted, is usually minimal to mild.