Of these factors, experiencing physical adverse events or health service discrimination had the strongest association with reporting difficulty taking ART, increasing the odds of reporting difficulty taking ART by

approximately four- to fivefold. Taking more than one ART dose per day, reporting poor to fair health and living in a regional centre GPCR Compound Library in vitro were associated with a two- to threefold increase in the odds of reported difficulty taking ART. Being older than 50 years of age, taking an ART regimen composed of an NNRTI and two NRTIs, and disagreeing with negative attitudes about ART were estimated to at least halve the odds of reporting difficulty taking ART. We found that a number of personal and treatment-related factors were independently associated with reported

difficulty taking ART, while social and disease-related factors were not. Of more than 70 personal, socioeconomic, treatment-related and disease-related factors investigated in our study, we found that 13 distinct variables were independently associated with reported difficulty taking ART. By chance alone we would have expected three or four significant associations. Specifically, poor or fair AT9283 in vivo self-reported health, diagnosis of a mental health condition, alcohol and party drug use, living in a regional centre, not believing in the benefits of ART, worrying about ART efficacy, thinking tablets were an unwanted reminder of HIV, taking more than one ART dose per day, and experiencing health service discrimination or physical symptoms were each independently associated with increased odds of reporting

difficulty taking ART. Being 50 years of age or older MTMR9 and taking an ART regimen composed of an NNRTI and two NRTIs was associated with reduced odds of reporting difficulty taking ART. The findings of our study fit well with the existing literature about factors that are associated with nonadherence to cART. We found that a number of factors that had previously been shown to be consistently or inconsistently associated with cART nonadherence demonstrated an independent association with reported difficulty taking ART – in particular, the association of medication side effects, dosing frequency, age, alcohol consumption, psychiatric comorbidity, health-related quality of life, and knowledge and beliefs about HIV and its treatment [9].