The existence of hepatic vein tributaries and connected with them big sinusoids, found In single areas, reveals the characteristic function of vascular sprouting. In line with the information obtained, it could be believed that regardless of the recovery of liver size, the regeneration procedure is certainly not complete. Regenerated liver undergoes a permanent means of change of hepatocytes’ size and shape, as well as the transformation associated with the vascular system, which will be the cornerstone for changes in the spatial architecture of the liver lobules.Analysis of liver matrix studies makes it obvious that knowledge about the connective tissue skeleton regarding the liver is certainly not systematized, the language is contradictory, and the concern associated with the feline infectious peritonitis building of some elements sometimes causes debate. We set a target to review the attributes of the building associated with connective tissue matrix associated with liver of numerous animals and wild birds so that you can determine and systematize general and certain patterns Biotic indices of the framework. The liver of animals with a gallbladder (pigs, sheep) and without a gallbladder (rats) and birds (domestic chickens with a gallbladder) ended up being studied by the types of anatomical preparation, histology, histochemistry, histotopography, immunohistochemistry, scanning electron microscopy of deterioration replicas and fluorescence microscopy. Into the liver of mammals and birds, connective structure membranes of numerous thicknesses and compositions around the portal tracts and hepatic veins tend to be revealed. These membranes tend to be connected in a variety of ways with one another, the liver pill together with intralobular community of connective muscle and develop an extracellular matrix, which strengthens the structure of this liver muscle and helps the organ maintain steadily its integrity in a variety of pathological problems.Despite the multifaceted effects of the medications provided for COVID-19treatment, the amount of the contaminated and death of patients increases which shows the insufficient effectiveness of medicines used to fight coronavirus infections in medical rehearse, and plainly reveals the need to develop brand new therapy tactics.In this analysis article are summarized and reviewed the literature data regarding specific popular features of COVID 19. Specific interest is directed at genetic characteristic of the virus ,to system of its invasion into the person system, replication and interection with ACE-2 receptors ,as well as into the standard goals for the activity of existing medicines with antiviral task against COVID-19. Presently, listed here medications are widely used to treat COVID-19 remdesivir, chloroquine, hydroxychloroquine (HCQ), ribavirin, lopinavir/ritonavir. Relating to a recently available theory of coronavirus treatment, the starting point for the process of action of a possible click here etiotropic drug may be the inhibition of the coronavirus primary protease (Mpro/3CLpro) while the papain-like protease (PLpro). On the list of drugs listed above, lopinavir functions through this method but is characterized by serious negative effects.It is emphasized that remdesivir as adenosine analog provides inhibitory activity on RNA reliant RNA-Polymerase,but there are controversial views about reduction in mortality during utilizing of this drug against COVID-19. The present paper analyzes the method of action of a possible etiotropic drug against coronavirus, which implies the replacement of the nucleotides involved in the means of interpretation regarding the virus along with their analogs utilizing the aim to “inhibit” the ribosome and prevent the production of viral proteins.The article presents a retrospective analysis of this concept of work-related and mental burnout syndrome in doctors in the area of mental health. The analysis of domestic and foreign clinical resources, biblio-semantic, analytical, and statistical analysis methods had found in work. The leading reasons for burnout and their particular aspects had identified. The study involved 224 respondents – the health staff associated with the regional psychiatric medical center in Vinnytsia. One of the subjects had been females – 84.8%, and men – 15.2%. Regarding the total number of topics, medical practioners accounted for 38.8% (87 folks), nurses – 61.2% (137 folks). The average chronilogical age of respondents among medical practioners had been 44.6±12.2 years, among SMP 37.2±11.4 years. Work experience in expert tasks was among physicians – 19.7±12.3 many years and SMP – 15.5±11.1 years. When it comes to experimental research had made use of, the psychodiagnostic approach to psychological fatigue Boyko V.V. while the adapted method of Vodopyanova N.E., the importance of this distinction, was assessed using pupil’s t-test (t). Suggestions for psychological state avoidance steps for mental health experts are suffering from.