J Virol 2008, 82:8771–8779.PubMedCrossRef 26. Deutsch E, Cohen A, Kazimirsky G, Dovrat S, Rubinfeld H, Brodie C, Sarid R: Role of protein kinase C delta in reactivation of Kaposi’s sarcoma-associated
herpesvirus. J Virol 2004, 78:10187–10192.PubMedCrossRef 27. Lan K, Murakami M, Choudhuri T, Kuppers DA, Robertson ES: Intracellular-activated Notch1 can reactivate Kaposi’s sarcoma-associated herpesvirus from latency. Virology 2006, 351:393–403.PubMedCrossRef 28. Kerur N, Veettil MV, Sharma-Walia N, Sadagopan S, Bottero V, Paul AG, Chandran B: Characterization of entry and infection of monocytic THP-1 cells by Kaposi’s sarcoma associated U0126 research buy herpesvirus (KSHV): role of heparan sulfate, DC-SIGN, integrins and signaling. Virology 2010, 406:103–116.PubMedCrossRef 29. Sadagopan S, Sharma-Walia N, Veettil MV, Raghu H, Sivakumar R, Bottero V, Chandran B: Kaposi’s sarcoma-associated herpesvirus induces sustained NF-kappaB activation see more during de novo infection of primary human dermal microvascular endothelial cells that is essential for viral gene expression. J Virol 2007, 81:3949–3968.PubMedCrossRef 30. Carpenter CL, Auger KR, Chanudhuri M, Yoakim M, Schaffhausen B, Shoelson S, Cantley LC: Phosphoinositide AZD8931 manufacturer 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa
subunit. J Biol Chem 1993, 268:9478–9483.PubMed 31. Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA: Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 1995, 378:785–789.PubMedCrossRef 32. Stambolic V, Suzuki A, de la Pompa JL, Brothers GM, Mirtsos C, Sasaki T, Ruland J, Penninger JM, Siderovski DP, Mak TW: Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 1998, 95:29–39.PubMedCrossRef 33. Montaner S: Akt/TSC/mTOR activation by the KSHV G protein-coupled
receptor: emerging insights into the molecular oncogenesis and treatment of Kaposi’s sarcoma. Cell Cycle 2007, 6:438–443.PubMedCrossRef 34. Sodhi A, Montaner S, Patel V, Gomez-Roman JJ, Li Y, Sausville EA, Sawai ET, Gutkind JS: Akt plays a central role in sarcomagenesis induced by Kaposi’s sarcoma herpesvirus-encoded G protein-coupled receptor. Proc Natl Acad Sci USA 2004, PTK6 101:4821–4826.PubMedCrossRef 35. Tomlinson CC, Damania B: The K1 protein of Kaposi’s sarcoma-associated herpesvirus activates the Akt signaling pathway. J Virol 2004, 78:1918–1927.PubMedCrossRef 36. Wang L, Dittmer DP, Tomlinson CC, Fakhari FD, Damania B: Immortalization of primary endothelial cells by the K1 protein of Kaposi’s sarcoma-associated herpesvirus. Cancer Res 2006, 66:3658–3666.PubMedCrossRef 37. Morris TL, Arnold RR, Webster-Cyriaque J: Signaling cascades triggered by bacterial metabolic end products during reactivation of Kaposi’s sarcoma-associated herpesvirus. J Virol 2007, 81:6032–6042.PubMedCrossRef 38.