J Nutr 2001,131(7):2049–2052.PubMed 48. Galban CJ, Maderwald S, Uffmann K, Ladd ME: A diffusion tensor imaging analysis of gender differences in water diffusivity within human skeletal muscle. NMR Biomed 2005,18(8):489–498.PubMedCrossRef 49. Zaraiskaya T, Kumbhare D, Noseworthy MD: Diffusion tensor imaging in evaluation of human skeletal muscle injury. J Magn Reson Imaging 2006,24(2):402–408.PubMedCrossRef

50. Kovarik M, Muthny T, Sispera L, Holecek M: Effects of beta-hydroxy-beta-methylbutyrate S3I-201 cost treatment in different types of skeletal muscle of intact and septic rats. J Physiol Biochem 2010,66(4):311–319. doi:10.1007/s13105–010–0037–3PubMedCrossRef 51. Kuhls DA, Rathmacher JA, Musngi MD, Frisch DA, Nielson J, Barber A, MacIntyre AD, Coates JE, Fildes JJ: Beta-hydroxy-beta-methylbutyrate supplementation in critically ill trauma patients. SIS3 nmr J Trauma 2007,62(1):125–131. doi:10.1097/TA.0b013e31802dca93. discussion 131–122PubMedCrossRef 52. Nissen S, Sharp R, Ray M, Rathmacher JA, Rice D, Fuller JC Jr, Connelly AS, Abumrad N: Effect of leucine metabolite beta-hydroxy-beta-methylbutyrate on muscle www.selleckchem.com/products/MG132.html metabolism during resistance-exercise training. J Appl Physiol 1996,81(5):2095–2104.PubMed 53. Edstrom E, Altun M, Hagglund M, Ulfhake B: Atrogin-1/MAFbx and MuRF1 are downregulated in aging-related loss of skeletal muscle. J Gerontol 2006,61(7):663–674.

54. Gomes MD, Lecker SH, Jagoe RT, Navon A, Goldberg AL: Atrogin-1, a muscle-specific F-box protein highly expressed during muscle tuclazepam atrophy. Proc Natl Acad Sci USA 2001,98(25):14440–14445.PubMedCrossRef 55. Clavel S, Coldefy AS, Kurkdjian

E, Salles J, Margaritis I, Derijard B: Atrophy-related ubiquitin ligases, atrogin-1 and MuRF1 are up-regulated in aged rat Tibialis Anterior muscle. Mech Ageing Dev 2006,127(10):794–801.PubMedCrossRef 56. Pattison JS, Folk LC, Madsen RW, Booth FW: Selected Contribution: Identification of differentially expressed genes between young and old rat soleus muscle during recovery from immobilization-induced atrophy. J Appl Physiol 2003,95(5):2171–2179.PubMed 57. Sacheck JM, Ohtsuka A, McLary SC, Goldberg AL: IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1. Am J Physiol Endocrinol Metab 2004,287(4):E591–601.PubMedCrossRef 58. Anthony JC, Yoshizawa F, Anthony TG, Vary TC, Jefferson LS, Kimball SR: Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway. J Nutr 2000,130(10):2413–2419.PubMed 59. Pimentel GD, Rosa JC, Lira FS, Zanchi NE, Ropelle ER, Oyama LM, Oller do Nascimento CM, de Mello MT, Tufik S, Santos RV: beta-Hydroxy-beta-methylbutyrate (HMbeta) supplementation stimulates skeletal muscle hypertrophy in rats via the mTOR pathway. Nutr Metab (Lond) 2011,8(1):11. doi:10.