In this approach, the entirety of selleckchem SB203580 the procedure is performed through one incision, which would be otherwise required for specimen extraction, and it is potentially associated with reduction of port-site and incision-related morbidity, reduced postoperative pain, and improved cosmesis [7, 10, 11]. As compared to other minimally invasive techniques, SILC has also been shown to provide additional benefits such as lower surgical blood loss and quicker recovery [7, 9, 12]. The utility of SILC for the curative intent of colon cancer has yet to be evaluated in a single-institution case-control study. The aim of this study was to evaluate the short-term outcomes following SILC for the management of colon cancer and to compare these results to the established conventional laparoscopic and hand-assisted laparoscopic modalities.

2. Methods The data from this study was obtained from an Institutional Review Board approved database. From July 2009 to October 2011, a total of 167 patients underwent SILC for benign and malignant colorectal diseases in our practice, among which 50 had resection for adenocarcinoma of the colon. These 50 patients represent the SILC arm of the study and were paired based on the diagnosis of cancer and type of colectomy with the last 50 patients who had undergone minimally invasive colectomy with the utilization of either conventional multiport or hand-assisted laparoscopic techniques. The latter represents the second study arm (MIS group), and the selection of conventional laparoscopic colectomy (CLC) or hand-assisted laparoscopic colectomy (HALC) was depending on surgeon preference.

The procedures were performed by one of two board certified colorectal surgeons with extensive experience in minimally invasive colorectal surgery (T. B. P. and E. M. H.). Demographic data including age, gender, body mass index (BMI), and history of previous abdominal surgery were analyzed. Intraoperative outcomes including estimated blood loss (EBL), operative time (OT), and conversion rate were assessed. Postoperative results were tabulated and analyzed following 30 days after discharge and included complication rate, length of stay (LOS), readmission rate, and reoperative intervention. Histopathologic characteristics including number of extracted lymph nodes, status of surgical margins, stage, and grade of tumor were assessed. 2.1.

Surgical Technique We have previously described our technique and port placement [8, 13�C16]. The SILC procedures were performed with the utilization of one of two single-port devices: SILS Port Multiple Instrument Access Port (Covidien, Mansfield, MA) or GelPOINT Entinostat Advanced Access Platform (Applied Medical, Rancho Santa Margarita, CA). A 30-degree 5mm standard laparoscope and conventional nonarticulating laparoscopic instruments were used for all procedures.