Hormone therapy with thyroxine is the choice of treatment in established hypothyroidism. http://www.selleckchem.com/products/U0126.html It normalizes the menstrual cycle, PRL levels and improves the fertility rate. Therefore, with simple oral treatment for hypothyroidism, 76.6% infertile women with hypothyroidism conceived after 6 weeks to 1 year of therapy. We tried to maintain normal TSH levels; compliance and adequacy of hypothyroid drug dose were checked by TSH measurement after 6 to 8 weeks interval. Therefore, the normal TSH levels are the pre-requisite requirements for fertilization. The decision to initiate thyroid replacement therapy in subclinical hypothyroidism at early stage is justified in infertile women. Our data also indicate that variations in TSH levels in the narrower range or borderline cases, i.e. 4�C5, 5�C6, and >6.

0 ��IU/ml, should not be ignored in infertile women which are otherwise asymptomatic for clinical hypothyroidism. This group of infertile women, if only carefully diagnosed and treated for hypothyroidism, can benefit a lot rather than going for unnecessary battery of hormone assays and costly invasive procedures. For better management of infertility cause, we should plan further studies with the large sample size and long-term follow-up which are necessary to validate the variation in TSH and PRL levels. Footnotes Source of Support: Nil. Conflict of Interest: None declared.
The effect of physical activity on brain and cognition has attracted the interest of many researchers in recent years, with an increasing number of reports indicating that both regular exercise as well as isolated acute bouts of exercise may benefit human cognitive processes.

[1] But there are conflicting reports regarding the type of cognitive processing that is most affected by aerobic exercise.[2,3] Measurement of event-related potentials (ERP) is a noninvasive technique to assess the function of the central nervous system (CNS).[4] ERPs are patterns of neuroelectric activation that occur in response to a stimulus. The amplitude of the P300 is directly related to the allocation of attentional resources during stimulus engagement.[5] The latency of the P300 is used for stimulus classification and for evaluation of speed, with increased latency indicating longer processing time.[6] Earlier studies have observed increased amplitude and shorter latency, relative to a basal state, following single acute bouts of moderately intense exercise.

[7] However, other researchers, examining a different aspect of cognition (other than cognitive P300), failed to demonstrate a beneficial effect of acute aerobic exercise.[8] Therefore, the present study was designed to study the effect of acute moderate exercise of short duration on the cognitive (P300) Cilengitide functions of young males and females with sedentary lifestyles.