Forty-four patients (44%) were given chemotherapy consisting of epirubicin/cisplatin/carboplatin or paclitaxel/carboplatin. Univariate and multivariate analyses were performed to identify

significant prognostic clinicopathological factors.

Results:

With a median follow-up time of 59.2 months, the 5-year overall survival was 74% for those 60 years or older versus 90% for those younger than 60 years (P = 0.044). For disease-free survival, it was 65% for those 60 years or older, versus 85% for those younger than 60 years (P = 0.013). On multivariate analysis, poor disease-free survival was associated with age >= 60 years (P = 0.035).

Conclusions:

Older patients (age >= 60 years) with endometrial cancer had significantly lower overall survival and disease-free survival following postoperative RT independent this website of other prognostic factors and/or treatment technique.”
“The pathogenesis of arterial thrombosis ABT-263 order is complex and dynamic. Unlike venous thrombi, arterial thrombi typically form under conditions of high blood flow and are mainly composed of platelet aggregates, giving them the appearance of ‘white clots’. Strong evidence suggests that arterial thrombi originate as a consequence of an injured atherosclerotic plaque, and that their formation involves the release of prothrombotic material (such as tissue factor), platelet aggregation, and platelet adhesion to the vascular

wall. The initially labile platelet plaque is then stabilized by insoluble fibrin produced upon activation of the coagulation cascade. Inherited genetic factors (gene polymorphisms) and acquired predisposing conditions (such as

the concentration and activity of clotting Selleckchem Peptide 17 factors) can influence both the composition and the size of an arterial thrombus. Further research is needed to elucidate the functions of blood coagulation proteins and cellular elements that are critical to the pathogenesis of arterial thrombosis. This Review explains mechanisms of pathological arterial thrombus formation and discusses genetic and acquired risk factors of atherothrombosis.”
“Objective: To compare the attitudes and opinions of otologists and neurologists regarding the cause, diagnosis, and management of vestibular migraine.

Study Design: Survey questionnaire.

Methods: An 18-question survey designed to elicit opinions about the cause, diagnosis, pathophysiology, and management of migraine and dizziness was mailed to the entire memberships of the American Neurotology Society (ANS) and the International Headache Society (IHS). Survey participant responses were recorded for physician practice characteristics and for opinions on various clinical features of vestibular migraine.

Results: Of the 917 surveys mailed, 146 were completed by ANS members and 110 by IHS members. The frequency of respondents listing symptom origin as central to a diagnosis of migraine was 43% for ANS members versus 62% of IHS members.