e. the strongest association between the drug and an adverse event) for pituitary tumors followed by haloperidol, ziprasidone and olanzapine. The incidence of reports of hyperprolactinaemia

and galactorrhoea were also higher with risperidone than with other antipsychotics. In the literature, hyperprolactinemia, one of the endocrinological side effects due to Selleck P450 inhibitor antipsychotics, has been frequently observed; however, pituitary macroadenoma has not been reported. Pituitary adenomas constitute 10–20% of all intracranial neoplasm [Erer et al. 2008]. The development of pituitary Inhibitors,research,lifescience,medical adenoma is considered to be multifactorial. It is thought that a somatic point mutation arises initially in one cell and the event progresses with secondary mutations. Environmental factors, growth factors, hormones and changes in receptors influence the behavior of biological changes in tumors Inhibitors,research,lifescience,medical [Shahlaie

et al. 2010]. Pituitary adenomas result in significant morbidity due to local pressure effects and hormone hypersecretions. Treatment requires the work of a team of brain surgeons, endocrinologists and radiation oncologists [Debono and Newell-Price, 2010]. The most common Inhibitors,research,lifescience,medical cause of acromegaly is pituitary adenomas synthesizing GH and it is a known risk factor for cardiovascular mortality. When GH secretion cannot be controlled in these patients, the metabolic changes result in mortality and/or morbidity. Compared with the general population, acromegalic patients have 2.4- to 4.8-fold increased mortality rate [Holdaway et al. 2004; Kauppinen-Makelin Inhibitors,research,lifescience,medical et al. 2005]. Elevated prolactin levels are seen in ~30% of patients [Komossa et al. 2011]. Although studies cannot establish the absence or presence of a causal relationship between second-generation antipsychotic agents treatment generally (and risperidone treatment specifically), and pituitary adenomas, it is important to recognize that pituitary adenomas of clinical relevance may still occur in Inhibitors,research,lifescience,medical patients receiving antipsychotic medication, and that patients with symptoms suggesting

pituitary adenomas should receive full appropriate evaluation. As with other second-generation antipsychotics, endocrinological side effects were identified and pituitary macroadenoma cases increasing with growth hormone due to risperidone treatment have been reported for the first time, which Thiamine-diphosphate kinase gives importance to our case study. According to Gianfrancesco and colleagues (as reported in the pharmacovigilance study by Szarfman et al. [2006]), compared with other antipsychotics, risperidone-treated patients were found to have a higher risk of the occurrence of pituitary tumors [Gianfrancesco et al. 2009]. This suggests that, when a high level of prolactin is detected in patients treated with risperidone, it is worth doing pituitary tumor research using brain imaging studies, because these tumors are usually small, benign and remain endocrinologically silent [Lopes, 2010].