Conclusions: This is the first report that demonstrates that a DNA prime/ poxvirus boost vaccination regimen induces low levels of malaria parasite growth inhibitory antibodies, which are boosted to high levels upon challenge. No association could, however, be established

between the levels of inhibitory capacity in vitro and protection, either after vaccination or after challenge.”
“The static and dynamic behavior of the Langmuir monolayers of poly(ester)s containing germanium and silicon in the main chain (Scheme 1) is reported. True monolayers are found for all the poly(ester) s studied. The isotherms of surface pressure versus surface area for poly (ester) s exhibit a behavior of the expanded-type monolayers and that of condensed-type monolayers. It was observed that the addition of an hydrophilic polymer such as RepSox nmr poly(monomethyl itaconate) to the water subphase produces significant changes in the isotherm properties. The interfacial rheology of the poly(ester) s monolayers has also been studied by

using Oscillatory Barrier Experiments in a low-frequency range. It was found this website that the elasticity and the dilational viscosity increase from diluted monolayers until a surface concentration about 20 x 10(-5) mg cm(-2). The static and dynamic elasticities were found to be very similar for the poly(ester) s over the dilute range. It was possible to conclude that these poly (ester) s form extremely viscoelastic

monolayers. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci 120: 3126-3132, 2011″
“Inhibition of sperm motility has recently become a promising target for male contraceptive development. AF-2364, an analogue of Lonidamine (LND), had a contraceptive effect when orally administered to adult Sprague-Dawley rats. LND can also target mitochondria to inhibit oxygen consumption and block energy metabolism in tumour cells. However, Selleckchem Talazoparib there are no reports of the effects of AF-2364 on human sperm function. Herein we describe the action of AF-2364 on human sperm in vitro, as well as the mechanisms involved. AF-2364 specifically blocked human sperm motility in vitro. Further experiments revealed that AF-2364 can target sperm mitochondrial permeability transition (MPT) pores to induce the loss of sperm mitochondrial membrane potential (Delta Psi m) and decrease ATP generation; however, no significant changes in the cytoskeletal network or the human sperm proteome were detected after exposure to AF-2364. Incubation of AF-2364 with other human or mouse cell lines indicated that the spermicidal effect at the lower concentration was specific. In summary, the spermicidal effect of AF-2364 involves direct action on sperm MPT pores, and this compound should be further investigated as a new spermicide candidate.