While it was ineffective in stopping kidney, colon and liver cancers studies with animal cancer models display that lycopene paid down tumor growth in breast, prostate and lungs. In a study utilizing a single dose of 2 uM lycopene partly demethylate GSTP1 gene and improved its mRNA expression in MDA MB 468 breast cancer cell line but RARB2 gene wasn’t demethylated in either MDA MB 468 or MCF 7 breast cancer cell lines. Lycopene treatment induced demethylation of the RARB2 and HIN 1 genes in the low tumorigenic MCF10A fibrocystic breast Everolimus 159351-69-6 cells. Lycopene also acts as a protective agent against ultra-violet induced carcinogenesis via inhibition of epidermal ornithine decarboxylase activity, maintaining normal cell growth, lowering inflammatory responses, and perhaps stopping DNA damage as indicated by blocking the necessitating step of apoptosis. This data show that lycopenemight have DNA demethylating potential however further research is required to comprehend the process of demethylation of gene promoter by lycopene. Ellagitannins are phytochemicals present in high levels in many fruits and nuts, including walnuts, raspberries, pomegranate and Gene expression almonds. These are polyesters of ellagic acid and a sugar moiety and upon ellagic acid is released by hydrolysis. Ellagitannins display anti oxidant and radical scavenging, anti-viral, antimicrobial, antimutagenic, anti inflammatory, anti growth selling and immunomodulatory properties. Ellagitannins elicit their anticancer effects by modulating transcription facets and signaling pathways which prevent cancer cells growth and induces apoptosis. Specifically, exposure of liver cancer cells with ellagitannin BJA3121 isolated from a place Balanophora japonica alteration in the expression of many miRNAs and resulted in cell growth inhibition. BJA3121 treatment led to up-regulation of miR let 7e, miR 370, miR 373 and miR 526b and down-regulation of let 7a, let 7c, let 7d which correlated with genes concerned in cell differentiation and growth. In addition ubiquitin-conjugating to the abovementioned dietary phytochemicals, a number of other natural dietary substances are under study for his or her ability to demonstrate chemopreventive/therapeutic potential through epigenetic change. Folic acid is a vitamin B within refreshed breakfast cereals, beans, several grains, green vegetables and vegetables. Folic acid is a key aspect in the methyl metabolic rate process. Deficiency of folic acid could modify hepatic DNA methylation patterns and produce liver cancer. Folic acid deficiencies are associated with the development of a number of different cancers including: lung, mind, chest, cervix, colorectal and ovary. Selenium is a nutrient within game meat, meat, chicken and Brazil nuts. It’s a vital elementwith antioxidant, proapoptotic, anti-cancer and DNA repair qualities.