3 vs.2.1/100 patient years, p = 0.055).
Conclusions:
A rapid pre-transplant course is a strong risk factor for transplant failure in patients with IgAN.”
“Gamma-linolenic acid (gamma-linolenic acid, GLA; C18:3 delta(6, 9, 12)) belongs to the omega-6 family and exists primarily in several plant oils, such as evening primrose oil, blackcurrant oil, and borage oil. delta(6)-desaturase is a key enzyme involved in the synthesis of GLA. There have been no previous reports
on the genes encoding delta(6)-desaturase in blackcurrant (Ribes nigrum L.). In this research, five nearly identical copies of delta(6)-desaturase gene-like sequences, named RnD8A, RnD8B, RnD6C, RnD6D, and RnD6E, were isolated from blackcurrant. Heterologous expression in Saccharomyces cerevisiae and/or Arabidopsis thaliana confirmed that RnD6C/D/E were delta(6)-desaturases that could use both alpha-linolenic acids (ALA; C18:3 CAL-101 delta(9,12,15)) and linoleic acid (LA; C18:2 delta(9,12)) precursors in vivo, whereas RnD8A/B were delta(8)-sphlingolipid desaturases. Expression of GFP tagged
with RnD6C/D/E showed that blackcurrant delta(6)-desaturases were located in the mitochondrion (MIT) in yeast and the endoplasmic reticulum (ER) in tobacco. GC-MS results showed that blackcurrant accumulated GLA and octadecatetraenoic acids (OTA; C18:4 delta(6,9,12,15)) mainly CA3 concentration in seeds and a little in other organs and tissues. RT-PCR results showed that RnD6C and RnD6E were expressed in all the tissues at a low level, whereas RnD6D was expressed at a high level only in seeds, leading
to the accumulation of GLA and OTA in seeds. This research provides new insights to our understanding of GLA synthesis and accumulation in plants and the evolutionary relationship of this class of desaturases, and new clues as to the amino acid determinants which define precise enzyme activity.”
“We report the third-order optical nonlinearity of ferroelectric thin films of Mn doped Ba0.6Sr0.4TiO3 using Z-scan measurement with femtosecond laser pulses at 800 nm. The nonlinear AZD7762 ic50 refraction index and two-photon absorption coefficient are measured to be 3.0 x 10(-4) cm(2)/GW and 1.7 cm/GW, respectively, which are about one order of magnitude larger than those of the undoped Ba0.6Sr0.4TiO3 thin films. The enhancement is attributed to the acceptor behavior of Mn ions dopant. The figure of merit, T, defined by T=beta lambda/n(2), was calculated to be 0.44, less than 1. The results indicate that the thin films have great potential applications in nonlinear photonic devices. (C) 2011 American Institute of Physics. [doi:10.1063/1.3527969]“
“Hepatorenal syndrome (HRS) is a complication of cirrhosis with a poor prognosis without transplantation. The aim of this study is to analyze the influence of extended criteria donors (ECD) on the postoperative outcome of recipients with HRS. The last 498 patients were divided according to pre-transplant type 1 or 2 HRS. Sixty-six (13.