23 The program appears to be a useful research tool in a PhD student laboratory.41 The MaZda package is available on the Internet.33 So far more than 300 researchers from all over the world have downloaded it onto their computers. Selected abbreviations and acronyms ANN artificial neural network LDA linear discriminant analysis NDA nonlinear Inhibitors,research,lifescience,medical discriminant analysis PCA principal component analysis ROI region of interest Notes This article is published following the 14th Biological Interface Conference held in Rouffach, France, between October 1 and 5,

2002, on the theme of “Drug Development.” Other articles from this meeting can be found in

Dialogues in Clinical Neuroscience (2002, Vol 4, No 4). Delivery of MRI images by Dr Richard Lerski of Dundee University and Inhibitors,research,lifescience,medical Hospital (buy SB203580 Figure 2a), Prof Milan Hajek of the Institute of Clinical and Experimental Medicine in Prague (Figure 4), Prof Lothar Schad of German Cancer Research Centre in Heidelberg (Figures 1 and 5), and Dr Michal Inhibitors,research,lifescience,medical Strzelecki (Figure 2) is very much appreciated.
The recent development of neuroimaging technologies that permit in vivo characterization of the anatomical, physiological, and receptor pharmacological correlates of mood disorders have enabled significant advances toward delineating the neurobiological correlates of mood disorders. Because these conditions were not associated with gross brain pathology Inhibitors,research,lifescience,medical or with clear animal models for spontaneous, recurrent, mood episodes, the availability of tools allowing noninvasive assessment of the human brain proved critical to illuminating the pathophysiology of major depressive disorder (MDD) and bipolar disorder (BD). The results of studies applying imaging technologies and postmortem studies have guided clinical neuroscience toward models in which both functional and structural brain pathology Inhibitors,research,lifescience,medical play roles

in the pathogenesis of mood disorders. Longitudinal positron emission tomography (PET) imaging studies of MDD and BD identified abnormalities of regional cerebral glucose metabolism and cerebral blood flow (CBF), which, in some cases, persisted beyond Sitaxentan symptom remission, and in other cases appeared mood state-dependent (reviewed in reference 1; Figure 1). These reversible abnormalities presumably reflect areas where metabolic activity increases or decreases to mediate or respond to emotional and cognitive manifestations of the depressive syndrome, because local glucose metabolism and CBF (which is tightly coupled to glucose metabolism) reflect summations of the energy utilization associated with terminal field synaptic transmission during neural activity.