1, 2, 3, 4 and 5Lansoprazole (b) is an antiulcer agent and proton pump inhibitor.4 and 5 Pantoprazole (c) suppresses the final step in gastric acid production by forming a

covalent bond to two sites of the (H+,K+)-ATPase enzyme system at the secretary surface of the gastric parietal cell.6 and 7Rabeprazole (d) is also demonstrated efficacy in healing and symptom relief of gastric and duodenal ulcers.2, 8 and 9Ilaprazole (e) is a proton pump inhibitor (PPI) used in the treatment of dyspepsia, peptic ulcer disease (PUD), and duodenal ulcer Fig. 1.10 The art has endeavoured to synthesize a variety of piperazine derivatives. Among the piperzine derivatives available as anti-ulcer drugs, 1-[2-(orthochloro-robenzydryloxy)ethyl]-4-(ortho-methylbenzyl)piperzine well known.11 and 12 The selection of well-known skeleton, strategic synthetic approach, technologies applied for reactions.

Lumacaftor in vitro The maximum anti-ulcerative drugs are prazoles. The prazoles skeleton considered for development of novel moieties into literature. The idea to incorporate the piperazine with pyridine derivatives of prazoles considered to design new skeleton (Fig. 2). A strategy of convergent synthesis, that aims to learn more improve the efficiency of multi-step chemical synthesis, most often in organic synthesis. In linear synthesis the overall yield quickly drops with each reaction step. Here in, the synthesis of two tiles derivatives and coupled considered easy and found excellent literature for easy synthesis of both ends approached convergent than linear. The reliable technology useful for Non-specific serine/threonine protein kinase reaching target is very important to reach target

very simple and cost effective. The second technology is the way of reaction conditions are using, for getting lesser reaction timings and high yield. The N-alkylation step differentiated via Micro Wave, Sonication and Conventional method. The microwave mediated organic reactions13b, 13 and 13a take place more rapidly, safely, and in an environmentally friendly manner, with high yields. Very little solvent and even the use of water as a solvent is a big advantage of microwave chemistry. Recently, microwave,14 and ultrasonication15 assisted synthesis in organic chemistry is quickly growing. Many organic reactions proceed much faster with higher yields under microwave irradiation compared to conventional heating. It has long been know that molecules undergo excitation with electromagnetic radiation is a technique for microwave synthesis.16 Ultra-Sonication reactions enhances the reaction rates up to a million times, believed to be due small cavities (100 microns) which implode, creating tremendous heat and pressure, shock waves, and particular accelerations.