05 level. Results Vestibulomotor behavior The vestibulomotor behavior of APP/PS1 KI and WT control mice is presented in Figure ?Figure1.1. As shown in Figure ?Figure1A,1A, no differences were observed between selleck chemicals llc APP/PS1 KI and WT mice in grip strength performance. Further, the grip strength remained consistent across the age groups for both APP/PS1 KI mice and their WT counterparts. Figure 1 Motor behavior of APP/PS1 KI and wild-type control mice. (A) No differences in grip strength are observed between amyloid precursor protein/presenilin-1 knock-in (APP/PS1 KI) mice and their wild-type (WT) counterparts in any age group. (B) No performance … No differences in beam walk performance were observed between genotypes or for any age group of mouse tested (Figure ?(Figure1B).1B).

The number of foot slips for both APP/PS1 KI and WT mice increased as the size of the bar decreased. APP/PS1 KI mice made 1.92 ?? 0.26 foot slips compared with 1.46 ?? 0.37 foot slips for the WT mice crossing the 3 cm beam. For the 2 cm beam, the APP/PS1 KI mice made 9.69 ?? 1.09 foot slips while the WT mice made 8.36 ?? 0.70 foot slips. Figure ?Figure1B1B also shows the APP/PS1 KI and WT mice performance on the 1 cm beam (APP/PS1 KI mice had 20.28 ?? 1.54 foot slips compared with 17.92 ?? 1.00 foot slips for WT mice). The open field behavioral task to assess ambulatory movement showed no difference between APP/PS1 KI and WT mice in distance traveled (Figure ?(Figure1C)1C) or in movement speed (Figure ?(Figure1D)1D) for any age group.

Similarly, no differences in habituation behavior were observed in the open field task for either genotype or for any age group (data not shown). Finally, no differences were observed at any age group between APP/PS1 KI and WT mice in rotor rod performance (Figure ?(Figure1E),1E), although the younger animals (7 months old) performed Anacetrapib this task somewhat better than the older age groups. Interestingly, performance was negatively correlated with the weight of the animals (Figure ?(Figure1E,1E, insert). Specifically, WT mice performance showed a highly significant negative correlation with weight (P = 0.004), and APP/PS1 KI mice showed a similar pattern that did not reach statistical significance (P = 0.052). Anxiety-related behavior The anxiety-related behavior of APP/PS1 KI and WT mice was assessed by two behavioral tests: analysis of time spent in the center zone versus peripheral zone of the open field arena; and the elevated plus maze task.

As shown in Figure ?Figure2A,2A, no differences were seen between APP/PS1 KI and WT mice, or between any age group of mice, in the amount of time each mouse spent in the open center zone of the open field behavioral task. Similarly, in the elevated plus maze task, both the APP/PS1 KI and WT mice spent more time in the enclosed arms compared selleck chemicals with the open arms, and this was consistent across all age groups (Figure ?(Figure2B).2B).