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“Background: The present study examined the influence of rapid intravenous fluid loading. (RFL) on airway structure and pulmonary vascular volumes using computed tomography imaging and the subsequent impact on pulmonary www.selleckchem.com/products/isrib-trans-isomer.html function in healthy adults (n = 16).
Methods and Results: Total lung capacity (Delta TLC = -6%), forced vital capacity (Delta FVC = -14%), and peak expiratory flow
(Delta PEF = -19%) decreased, and residual volume (Delta RV = +38%) increased post-RFL (P < .05). Airway luminal cross-sectional area (CSA) decreased at the trachea, and at airway generation 3 (P < .05), wall thickness changed minimally with a tendency for increasing in generation five (P = .13). Baseline pulmonary function was
positively associated with airway luminal CSA; however, this relationship deteriorated after RFL. Lung tissue volume and pulmonary vascular volumes increased 28% (P < .001) post-RFL, but did not fully account for the decline in TLC.
Conclusions: These data suggest that RFL results in obstructive/restrictive PF changes that are most likely related to structural changes in smaller airways or changes in extrapulmonary vascular beds. (J Cardiac Fail 2010;16:175-185)”
“Abnormalities of copper (Cu) and zinc (Zn) are involved in the etiology and pathogenesis of vitiligo. However, controversial results exist now on Cu and Zn in serum of vitiligo patients. PHA-848125 The purpose of this study is to compare the Small molecule library in vitro serum levels of Cu and Zn between vitiligo patients and healthy controls. In the meta-analysis, 16 studies with a total of 891 vitiligo cases and 1682 healthy controls were included. The levels of serum Cu and Zn were compared between groups of case and control. The serum levels of Cu were significantly lower in vitiligo
patients than in healthy controls (Z=4.04, PSMD], -0.9; 95% confidence interval [CI], -1.34 to -0.47). The levels of serum Zn were also significantly lower in vitiligo patients than in healthy controls (Z=4.88, PSMD, -1.09; 95% CI, -1.51 to -0.64). These results demonstrate that decreased levels of serum Cu and Zn are generally present in Chinese vitiligo patients. This may offer support for clinical administration of oral Cu and Zn supplements.”
“The aim of this research was to determine and compare the distribution by sex and age of pharyngoamygdalitis cases and analyze quantitatively and qualitatively the applied treatments in Hospitals A (HA) and B (HB) of San Luis city, Argentina. An observational, descriptive, transversal and indication-prescription’s study was carried out. Diagnoses and drugs were classified and the prescriptions were analyzed. Amoxicillin in HA and penicillin G benzathine in HB were mainly prescribed. Antihistamines, mucolytics and antitussives of non-elevated therapeutic value were used.