Intervention: CIs were removed with aseptic technique and processed for microbial identification.
Main Outcome Measure: CI microbes were identified with routine culture and speciation and 16s deoxyribonucleic acid 454-pyrosequencing.
Results: All CIs had evidence of microbes. Propionibacterium acnes and Acidovorax facilis were more
common on noninfected CIs (p = 0.005, 0.031). Selleckchem GSK3326595 Staphylococcus aureus was more common on infected CIs (p = 0.003). The microbial profiles associated with CI infection were different from, but overlapped with those of noninfected CIs. Microbial culture with selective media identified pathogens not identified on pyrosequencing.
Conclusion: Bacteria are present on all CIs, both with and without evidence of clinical infection, but species differ with clinical status. Empiric therapy
for CI infections should include coverage for S. aureus. Gene pyrosequencing and selective culture techniques may yield complementary results that may impact the management JNJ-26481585 in vivo of CI infections.”
“Background and objective: Genome-wide association studies (GWAS) have identified the three chromosomal regions, 5p15, 6p21 and 15q25, as being associated with lung cancer risk in European populations. This study was performed to confirm these associations in Korean patients with lung cancer. Methods: The genotypes at rs2736100, rs402710, rs401681 and rs31489 at 5p15, rs9295740 at 6p22, which is in extensive linkage disequilibrium with the 6p21 region, as well as rs2036534 and rs6495309 at 15q25, were determined in 1094 patients with lung cancer and 1100 healthy control subjects, who were frequency matched for age and gender. Results: The single-nucleotide polymorphisms (SNP) at 5p15 (rs2736100, adjusted odds ratio [aOR] 1.32,95% confidence interval [CI] 1.03-1.67, P = 0.025; rs402710, aOR 0.82, 95% CI 0.69-0.98, P = 0.025; rs401681, aOR 0.82, 点击此处 95% CI 0.69-0.98, P = 0.026) and at 15q25 (rs2036534, aOR 0.75, 95% CI 0.61-0.93, P = 0.01; rs6495309, aOR 0.81, 95% CI 0.65-1.00, P = 0.052) were significantly associated with lung cancer risk. The magnitude of the effect
was similar to that reported in previous studies, and the association was in the same direction. The effect of SNP in the 5p15 region on the risk of lung cancer was significant only for adenocarcinoma. The two SNP in the 15q25 region were significantly associated with lung cancer risk in ever-smokers and in patients with squamous-cell carcinoma. However, there was no association between the SNP at 6p22 and lung cancer risk. Conclusions: The association between SNP in the 5p15 and 15q25 regions and the risk of lung cancer was confirmed in a Korean population.”
“Purpose: Long lasting usage of complete dentures causes lower occlusal vertical dimension, producing potential detrimental consequences. The aim of this study was to investigate how changes in vertical dimension during denture exchange affect muscular activity and hyoid bone position.