The patients investigated mainly for possible side effects of deferasirox. No negative effect was seen in aspartate aminotransferase (AST), alanine aminotransferase (ALT), hemoglobin (Hb), and donor chimerism of the patients while serum ferritin levels significantly reduced (P = .018). Although serum creatinin significantly increased find more (P = .034), it was in normal limits in all patients. The authors believe that this report shows promising findings to plan further studies to clarify clinical safety and efficacy of deferasirox in posttransplant period.”
“The P2X7 receptor has been found to be linked to an increased risk for tuberculosis in some populations.

In this study, we investigate whether the P2X7 receptor plays a role in increasing susceptibility to tuberculosis in Tunisia. We examined two 1513A/C and – 762T/C polymorphisms at the P2X7 receptor in 168 patients with pulmonary TB (pTB), 55 patients with extrapulmonary TB (epTB) and 150 blood donors from Tunisia. Genotyping of 1513A/C Dorsomorphin and – 762T/C polymorphisms was performed in purified genomic DNA using PCR-restriction fragment length polymorphism and allele-specific PCR, respectively. The 1513C, CC and AC loss-of-function allele and genotypes were overrepresented in the epTB group compared with the control group (45% vs. 17%, P = 10(-8); 24% vs. 4%, P = 3 x 10(-7); 42% vs. 27%, P = 10(-3), respectively). Additionally, they were associated with

3.83-, 11.86- and 3.15-fold risks of developing this clinical tuberculosis form, respectively. No associations between the – 762T/C polymorphismand tuberculosis disease, as well as disease anatomic location were

observed. Collectively, our results suggest that the P2X7 1513A/C loss-of-function polymorphism may contribute to susceptibility to epTB in Tunisian populations.”
“We report on the magnetic properties of epitaxial cobalt-ferrite films with orientations parallel to [001] and [111] grown by a reactive molecular beam epitaxy method using pure ozone gas as an oxidation agent. Both Mossbauer spectroscopy and magnetization measurement of the CoFe2O4(001) film grown on MgO(001) indicate that the film has perpendicular magnetic anisotropy (PMA) with high coercivity, whereas the film of CoFe2O4(111) grown on alpha-Al2O3(0001) appears to be paramagnetic. The maximum uniaxial anisotropy energy for CoFe2O4(001) estimated from the magnetization and coercivity HCS assay at room temperature is approximate to 3 x 10(6) erg/cm(3). (C) 2011 American Institute of Physics. [doi:10.1063/1.3566079]“
“This investigation was undertaken to evaluate the significance of solitary bony abnormalities on bone scintigrams of children with known or suspected malignancy. A total of 215 bone scans were performed in 183 children in order to look for possible metastasis over a 10-year period. Forty-nine scans (22.8%) were found to have single lesions, of which 18 were due to uptake at the primary site and were excluded from further consideration.