Lab Invest 2006, 86:687–696.PubMedCrossRef 42. Saxena NK, Sharma D, Ding X, Lin S, Marra F, Merlin D, Anania FA: Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular
carcinoma cells. Cancer Res 2007, 67:2497–2507.PubMedCrossRef 43. Schmitz KJ, Wohlschlaeger J, Lang H, Sotiropoulos GC, Malago M, Steveling K, Reis H, Cicinnati Inhibitor Library research buy VR, Schmid KW, Baba HA: Activation of the ERK and AKT signalling pathway predicts poor prognosis in hepatocellular carcinoma and ERK activation in cancer tissue is associated with hepatitis C virus infection. J Hepatol 2008, 48:83–90.PubMedCrossRef 44. Lou L, Ye W, Chen Y, Wu S, Jin L, He J, Tao X, Zhu J, Chen X, Deng A, Wang check details J: Ardipusilloside inhibits survival, invasion and metastasis of human hepatocellular carcinoma cells. Phytomedicine 2012, 19:603–608.PubMedCrossRef 45. Chen JS, Wang Q, Fu XH, Huang XH, Chen XL, Cao LQ, Chen LZ, Tan HX, Li W, Bi J, Zhang LJ: Involvement of PI3K/PTEN/AKT/mTOR pathway in invasion and metastasis in hepatocellular carcinoma: association with MMP-9. Hepatol Res 2009, 39:177–186.PubMedCrossRef 46. Tang CH, Tsai CC: CCL2 increases MMP-9 expression and cell motility in human chondrosarcoma cells via the Ras/Raf/MEK/ERK/NF-kappaB signaling pathway. Biochem Pharmacol 2012, 83:335–344.PubMedCrossRef
47. Wang J, Lu Y, Wang J, Koch AE, Zhang J, Taichman RS: CXCR6 induces prostate cancer progression by the AKT/mammalian target of rapamycin signaling pathway. Cancer Res 2008, 68:10367–10376.PubMedCrossRef
48. Hsiang CY, Wu SL, Chen JC, Lo HY, Li CC, Chiang SY, Wu HC, Ho TY: Acetaldehyde induces matrix metalloproteinase-9 gene expression via nuclear factor-kappaB and activator protein 1 signaling pathways in human hepatocellular carcinoma cells: association with the invasive potential. Toxicol Lett 2007, 171:78–86.PubMedCrossRef 49. Li J, Lau GK, Chen L, Dong SS, Lan HY, Huang XR, Li Y, Luk JM, Yuan YF, Guan XY: Interleukin 17A promotes hepatocellular carcinoma metastasis via NF-kB induced Temsirolimus concentration matrix metalloproteinases 2 and 9 expression. PloS one 2011, 6:e21816.PubMedCrossRef Competing interests The learn more Authors declared that they have no competing interests. Authors’ contributions JFC and ZGR conceived and designed the study, YHW, YYD, WMW, XYX performed the experiments and analyzed the data, YHW and YYD wrote the manuscript. ZMW, RXC contributed statistical analysis. JC, DMG supervised cell and animal experiment. All authors read and approved the final manuscript.”
“Introduction Primary breast cancer is one of the main public health problems worldwide. Over 1.3 million women are diagnosed annually with primary breast cancer and approximately 458,000 will die from the disease [1].